How PEA Works

How PEA Works

What Is PEA?

and how it works

Palmitoylethanolamide (PEA) is a natural and powerful way to manage pain, inflammation, and damage from oxidative stress. PEA is made in a similar way in humans and in plants, and it can be isolated from peanuts, soy, egg yolks, and other food sources.

How PEA Has Been Used

to naturally reduce pain

Since the late 1950s, PEA has been known to be an effective method of managing allergic and inflammatory reactions. Like many natural products, PEA exerts its action through multiple pathways.

One of these involves the stimulation of peroxisome proliferator-activated receptors (PPAR) which regulate gene expression.

Another way is by stimulating TRPV1 receptors which can cause inflammation and pain when they are sensitized.

Another is to simply downregulate mast cell production and degranulation. This works through the Autacoid Local Injury Antagonism (ALIA) system. PEA also stimulates the GPCR-55 cannabinoid receptor and also indirectly activates the CB-1 and CB-2 receptors by modulating FAAH.

The amazing, therapeutic effects of PEA are developed through the synergistic (additive) actions of these various mechanisms. These actions are particularly important in the central and peripheral nervous systems.

Read More: The Complete Beginner’s Guide To PEA

Expertly Formulated PEA Products

and what you need to look for

As we develop more products for Well Theory, we make sure to include the latest in natural wellness – choosing to support your health holistically, instead of resorting to heavy pharmaceuticals.

PEA, like CBD, works to relieve pain naturally, effectively, and quickly. 

The ingredients combined within our new PEA products work together to regulate homeostasis, reduce inflammation, and support stronger, healthier muscles.

Our new Pain Relief + Recovery Cream if formulated with PEA, Menthol, Aloe, Shea Butter, and other holistic ingredients to give you a holistic alternative to soothe away pain in sore muscles, joints, and more. 

We also formulated our Foot Pain Relief Cream with PEA, Lidocaine, and a blend of essential herbs to provide potent, natural relief that lasts. Lidocaine blocks the sensation of pain, numbing the application site instantly, while PEA sinks into the skin alongside soothing essential oils to reduce inflammation, soothe away soreness, and get you back to feeling your best self.


Dr. Meredith Warner is the creator of Well Theory and The Healing Sole. She is a board-certified Orthopedic Surgeon and Air Force Veteran.

She is on a mission to disrupt traditional medicine practices and promote betterment physically, spiritually and mentally to many more people. She advocates for wellness and functional health over big pharma so more people can age vibrantly with more function and less pain.

At Well Theory, Our surgeon-designed products are FDA Registered and formulated to help people:

  • Manage the symptoms of musculoskeletal pain
  • Recover vibrantly from orthopedic related surgeries
  • Fill the gaps in our daily diets
  • Manage pain associated with inflammation

Surgeon Formulated
For Your Peace of Mind

Natural Ingredients + Cutting-Edge Medical Breakthroughs.