How Oxidative Stress Harms Nervous System Health

How Oxidative Stress Harms Nervous System Health

What Is Neurodegeneration?

Neurodegeneration is characterized by the progressive loss of selective neural subtypes in the CNS (central nervous system).

Accumulating evidence shows this is mediated by mitochondrial damage.

The common mechanism for lifestyle and non-communicable chronic diseases (NCDs) is mitochondrial dysfunction.

The Role Mitochondria Play In Nervous System Health

Mitochondria are responsible for energy production in cells; they produce the fuel used by all other cellular processes.

Think of mitochondria as a central processing unit; it takes external nutrient input and then produces energy output. Energy is in the form of ATP (adenosine triphosphate) and they also produce important lipid species and provide metabolic substrates for post-translational modifications for cell signaling by DNA.

Part of the process of the electron transport chain (ETC) which is how mitochondria make energy is a byproduct called ROS (reactive oxygen species). These unpaired electrons or free radicals can damage the mitochondria, mitochondrial DNA and other cellular processes. 

The mitochondria have a system to check the ROS from damaging cells, but it is often overwhelmed due to chronic inflammation and excessive oxidative stress.

The mitochondria create energy from nutrients in the inner mitochondrial membrane. Here in the oxidative phosphorylation chain superoxide is made. 

This is a common ROS in the cell formed at complexes I and III during the ECT. This is formed when an oxygen molecule gains an electron. The superoxide anion is then converted to hydrogen peroxide by superoxide dismutase (SOD); this is an important ROS producing enzyme. 

 

The H2O2 molecule can then become a massively damaging hydroxyl radical; this is highly reactive and causes oxidative damage to everything it touches.

ATP is made from ADP in the mitochondria by ATP synthase; this charges the battery of the cell. ATP is the main form of energy and is able to discharge the energy whenever needed by other cells and cell processes.

2ADT molecules can also be converted to an AMP and and ATP molecule by adenylate kinase; these levels of AMP are monitored by AMPK. If AMPK senses too much AMP, then the cell is under-energized. Likewise, too little AMP means the cell is making too much energy.

Low energy states prompt AMPK to initiate protective functions and longevity functions of the cell.

 

The Importance Of Supporting Healthy Mitochondria:

The brain and nervous system require a massive amount of energy to function, and this energy is provided by mitochondria.

Dysfunctional mitochondria basically can’t adapt to a changing environment. Normally, these organelles inside our cells are able to change according to demand. The demand changes according to the stress applied and environment.

Read More: Why You Should Protect Your Mitochondria – And How To Do It

Neurons are generally very long-lived cells; they do not turn over very fast. This means that neurons accumulate damage over time. 

Mitochondrial failure causes too little energy to be produced and not enough repair and detoxification ability for the brain. 

This ultimately results in neuroinflammation and neurodegeneration.

The mitochondria play a critical role in nerve and neuron function. Cells in the PNS (peripheral nervous system) and CNS rely on mitochondrial integrity. Aberrant mitochondrial quality control plays a large role in degeneration of the nervous system. 

Human cells have developed systems for mitochondrial quality control to protect cells from the overproduction or under-neutralization of reactive oxygen species.

Mitochondrial quality control includes:

  • Proteostasis
  • Biogenesis
  • Dynamics
  • Mitophagy
  • Autophagy

Mitochondrial Dysfunction And Inflammation:

A key cause of inflammatory pathways is failure of mitochondrial biogenesis, or biogenetic failure. In these situations there is an increase in calcium levels in the cytoplasm, there is oxidative stress (from ROS) and there is a decrease in normal mitochondrial DNA.  

Mitochondria undergo fusion and fission on a continual basis.  Fusion allows for more energy production.  Fission allows for the repair or removal of damaged mitochondrial DNA and organelles.  A failure of either will lead to an accumulation of inflammation and ROS within the brain which then damages neurons.   

Mitochondrial fission regulates the release of pro-inflammatory mediators.  It does so through nuclear factor kappa light chain enhancer of activated B cells (NF-kB) and MAPK (mitogen activated protein kinase) signaling.  Chronic activation of microglial (CNS support cells) can contribute to neuronal defection.  

One theory is that the accumulation of mitochondrial ROS activates the NLRP3 inflammasome-dependent pathway that elicits chronic inflammation. The NLRP3 inflammasome complex triggers the production of pro-inflammatory cytokines and induces mitochondrial fragmentation. This impairs energy production and disrupts the CNS cell balance.

While the NLRP3 inflammasome complex is crucial for defense against pathogens, it is also the source of many NCDs (AD, gout, autoinflammatory disease, DM, atherosclerosis). Precise control of the NLRP3 inflammasome pathway is mandatory for the health of the cell.

How To Improve Mitochondrial Health

There are ways to improve the function and quality of mitochondria. Two well-known and studies methods are calorie restriction and exercise. Both methods employ a negative balance in terms of nutrient input and energy output needs. By producing a negative balance, the mitochondria are challenged. A challenged mitochondria will improve its function and abilities. 

The challenged mitochondria is better at biogenesis, energy production and other tasks. The unchallenged mitochondria fragments and fails; this is the heart of the NCD problem.

There is a profound effect on mitochondria by exercise. Sustained strenuous physical exercise can double the mitochondrial contents and activity. It will also increase the coupling of mitochondria and improve efficiency and function. 

One of the ways that enhance function of mitochondria during calorie restriction or exercise is the AMPK (AMP-activated protein kinase) path. AMPK is an energy sensor. This molecule is deacetylated during fasting or exercise by SIRT-1. Deacetylation of AMPK increases its activity. 

AMPK functions to sense energy imbalances in the cell and then to initiate cell protection. When the energy supply is low, the cell and organism will respond by slowing down aging and increasing protection from many age-related problems.

Providing antioxidants also improves mitochondrial function by allowing for excessive levels of ROS to be removed from the organelles and cells. Additionally, anti-inflammatory molecules also improve function by protecting the cell membranes and changing the environment of chronic inflammation to a more healthy one.

Less inflammation means less reactive oxygen species and less oxidative stress.

There must be harmony in the generation of mitochondrial components from the nuclear and mitochondrial genomes. This is achieved by the PPAR-gamma, SIRT1 and AMPK signalling pathway. There must be a balance between mitochondrial fusion and fission.

Fusion is the interconnection and enlargement of mitochondria to produce more energy. Fission is the repair/replace cycle for damaged mitochondria. For example, an abnormal accumulation of autophagy vacuoles from fission is a prominent feature of neurons in AD.

Defective oxidative phosphorylation in the mitochondria leads to excessive amounts of ROS and therefore elevation of oxidative stress. This causes more mitochondrial damage and a negative feedback loop happens. The role of antioxidants and anti-inflammatories is to stop this loop and to remove the unneeded ROS.

Many of our products are designed to help reduce inflammation. In particular, our Nervous System Multi is designed to improve neural health by optimizing mitochondrial function.

ABOUT THE AUTHOR

Dr. Meredith Warner is the creator of Well Theory and The Healing Sole. She is a board-certified Orthopedic Surgeon and Air Force Veteran.

She is on a mission to disrupt traditional medicine practices and promote betterment physically, spiritually and mentally to many more people. She advocates for wellness and functional health over big pharma so more people can age vibrantly with more function and less pain.

At Well Theory, Our surgeon-designed products are FDA Registered and formulated to help people:

  • Manage the symptoms of musculoskeletal pain
  • Recover vibrantly from orthopedic related surgeries
  • Fill the gaps in our daily diets
  • Manage pain associated with inflammation

Surgeon Formulated
For Your Peace of Mind

Natural Ingredients + Cutting-Edge Medical Breakthroughs.

100% NATURAL PAIN RELIEF FOR PEOPLE WORLDWIDE

What Are Inflammatory Markers, And Why You Should Check Them

What Are Inflammatory Markers, And Why You Should Check Them

Chronic inflammation is a type of slow, long-term and damaging inflammation that lasts for a prolonged period of time. It may last from several months, up to many years – and you may not be aware that you’re experiencing it. 

In the modern world, such low-grade inflammation starts in childhood and lasts until the end of life (generally speaking).

This type of inflammation is hard to discover. You likely won’t see swelling like you would around a cut or a bruise. Instead, you may simply feel sore, have achy muscles, or may feel fatigued. Most noncommunicable (you can’t ‘catch’ it) diseases are due to this phenomenon.

Keep reading to learn more about low-grade and chronic inflammation, what your inflammatory markers are, and how to get them tested:

The Harmful Effects Of Chronic Inflammation

Inflammation is actually a response from your immune system. In a healthy, well-balanced system, inflammation is used to fight infection and maintain proper systems operations. 

This will cause acute swelling that protects recently injured areas from further damage, isolates healthy cells from damaged ones, and is used to remove illnesses and viruses from the body.

But when inflammation goes unchecked, it can lead to a host of health issues. One example study asserts that “systemic chronic inflammation” can lead to deadly diseases like heart disease, certain cancers, diabetes, kidney disease, and more. 

The worst part about chronic inflammation is that often, its symptoms go unnoticed. Actually, the symptoms are noticed, but usually the root cause is never diagnosed. This can then lead to serious health problems across the lifespan.

How To Tell If You Have Chronic Inflammation

Since it’s nearly impossible to determine whether or not you’re experiencing chronic, low-grade inflammation by looking in a mirror or assessing how you feel (many of the symptoms of this type of inflammation can also point to other types of illness,) you should consider taking a blood test. 

Blood testing for chronic inflammation is in its infancy, but there are some markers that are available and might even be covered by your insurance. These are the most common blood tests you can take:

  • CRP (High sensitivity)
    These tests serum levels of CRP (C-reactive protein.) C-reactive proteins are also called “acute phase” proteins. The level of CRP in your blood increases when you have certain diseases that can cause inflammation – like sepsis, autoimmunity, and even certain cancers. This marker is now used to assess risk of cardiac disease too.
  • IL-6
    Interleukin-6 (IL-6) is an inflammatory protein produced by a variety of immune cells. It plays a role in regulating immune responses – so it’s a good way to tell if your immune system has been activated. This protein can be elevated in the presence of inflammation, infection, autoimmunity, cardiovascular diseases, and cancers. IL-6 exists within the ‘pro-inflammatory’ group of cytokines.
  • TNF-alpha
    TNF-alpha stands for “Tumor necrosis factor-alpha.” This is a cytokine (inflammatory protein) involved in physiological processes that control inflammation, homeostasis, and anti-tumor responses. If this level is high, it’s pointing to a high level of inflammatory cytokines. This protein is often elevated in the face of autoimmune disorders.
  • ESR
    Erythrocyte sedimentation rate (ESR or sed rate) is a test that measures the amount of inflammation present in the body. It measures the rate of sedimentation of red blood cells (how many “settle”) at the bottom of a thin, vertical tube. These cells settle faster if there are high levels of inflammatory proteins in the blood. The ESR is a great method of screening for inflammation but is not very specific.
  • HbA1c
    A hemoglobin A1c (HbA1c) test measures the amount of blood sugar (glucose) in your red blood cells that has been present for the past three months. It shows the average amount of glucose attached to hemoglobin (the part of your red blood cells that carries oxygen from your lungs to the rest of your body,) and is a good indicator of diabetes. If your levels are high, you may be at risk of diabetes, which can lead to concerning conditions like nerve damage. The A1C is actually measuring the amount of advanced glycated end-products that have attached to red blood cells. AGE is a marker of oxidative stress and low-grade inflammation. AGE is also considered a measure of ‘metabolic memory’ and can be used to show overall stress on the system.
  • Homocysteine
    This test measures the amount of homocysteine, a type of amino acid, in your blood. Your body uses homocysteine to make proteins. Vitamins B12 and B6, along with folic acid help convert homocysteine into what your body needs, so there should be little homocysteine left in your body. If you have higher levels than normal, it could be a sign of vitamin deficiency or heart disease. This serum level will denote either vitamin deficiency or elevated levels of inflammation. Certain anti-inflammatory compounds have been shown to decrease serum levels of homocysteine (resveratrol, aspirin, salicylic acid).

Well Theory: Natural Medicine Takes Time

When taking natural medicines, results can take a little longer than pharmaceutical methods and results may vary. 

Our products are formulated with higher doses to deliver steady results over time.

Our products are designed to naturally relieve pain, promote balance, and provide antioxidant support to help reduce inflammation and improve your overall health. Natural methods of reducing pain, oxidative stress, inflammation, and more should be considered a long-term investment in your overall well-being. 

These examples of inflammatory markers are just that, examples. 

Please consult with your physician if you are concerned about chronic and low-grade inflammation and wish to have testing.

ABOUT THE AUTHOR

Dr. Meredith Warner is the creator of Well Theory and The Healing Sole. She is a board-certified Orthopedic Surgeon and Air Force Veteran.

She is on a mission to disrupt traditional medicine practices and promote betterment physically, spiritually and mentally to many more people. She advocates for wellness and functional health over big pharma so more people can age vibrantly with more function and less pain.

At Well Theory, Our surgeon-designed products are FDA Registered and formulated to help people:

  • Manage the symptoms of musculoskeletal pain
  • Recover vibrantly from orthopedic related surgeries
  • Fill the gaps in our daily diets
  • Manage pain associated with inflammation

Getting Rid of Gout

Getting Rid of Gout

How To Prevent & Treat

gout flare-ups

Gout is a sophisticated form of arthritis, one that’s characterized by the quick and severe waves of pain, tenderness, and redness – often in the big toe. 

It can subside, bringing days without pain, only to be followed by another onset of attacks, known as flare-ups. There is no cure for gout, although prevention and management techniques exist to reduce the side effects of this painful illness.

How Is Gout Caused?

Gout is caused due to too much uric acid in the blood. High levels crystallize the acid, which forms around the bone or cartilage. The exact cause can be attributed to genetics, diet, and various medical conditions. 

Those with gout cannot process these crystals properly, and so they collect in the joint.

Genetics has the strongest influence on your uric acid levels, while medical conditions can also affect them, with diet far behind. For the latter, it is believed that a healthy diet, mixed with exercise, can help manage uric levels. Specifically, avoiding foods such as shellfish, red meat, and beer help to control gout.

How Can You Prevent Gout?

The best way to prevent gout is to focus on your uric acid levels, doing what you can to keep them under control. Achieving this involves lifestyle and dietary changes, focusing on drinking plenty of fluids to flush out the uric acid, as well as eating foods with low levels of purine (the compound that creates uric acid).

To manage your uric acid levels, you should lead a healthy lifestyle. That being said, there is no sure-fire, end-all solution out there, only ways to lower your uric acid levels. 

There is no available pharmaceutical explicitly used to treat gout, just medication to treat other illnesses that help with controlling uric acid levels associated with gout.

What Do You Do

during a flare-up?

Prevention is an excellent method of dealing with gout; however, if you already have it, what do you do during a flare-up to alleviate the pain? Let’s assume you are woken up in the middle of the night by an attack: first, you need to schedule an appointment with a doctor as soon as you can.

Gout is usually not life-threatening, but getting treatment within the first 24 hours of the start of attack is recommended. Professional help is recommended to treat flare-ups.

Generally, a physician will first advise you to take some anti-inflammatory, over-the-counter medicine such as Motrin, Advil, or Aleve. Do not take any aspirin, as it can make the flare-up worse. 

You can also create an ice pack for yourself, putting it on the affected area, and drink plenty of fluids while you do this. Take the pressure off your foot and elevate it so that it’s higher than your heart.

Avoid alcohol and try to relax – there’s not much else you can do until you see your doctor. Also, if you don’t have any allergies to them, consider eating tart cherries or tart cherry extracts for management of gout. 

ABOUT THE AUTHOR

Dr. Meredith Warner is the creator of Well Theory and The Healing Sole. She is a board-certified Orthopedic Surgeon and Air Force Veteran.

She is on a mission to disrupt traditional medicine practices and promote betterment physically, spiritually and mentally to many more people. She advocates for wellness and functional health over big pharma so more people can age vibrantly with more function and less pain.

At Well Theory, Our surgeon-designed products are FDA Registered and formulated to help people:

  • Manage the symptoms of musculoskeletal pain
  • Recover vibrantly from orthopedic related surgeries
  • Fill the gaps in our daily diets
  • Manage pain associated with inflammation

Surgeon Formulated
For Your Peace of Mind

Natural Ingredients + Cutting-Edge Medical Breakthroughs.

100% NATURAL PAIN RELIEF FOR PEOPLE WORLDWIDE

The Science Behind Aging

The Science Behind Aging

We all get old someday. But the loss of mobility, memory, and wellness that most of us associate with aging doesn’t have to impact you as much as you think. 

Keep reading to learn more about the science behind aging – and what you can do to age vibrantly.

Aging And Oxidative Stress

Longevity depends upon cellular metabolism and the control of ROS byproducts. ROS byproducts, or free radicals, are created through your body’s natural processes. 

Free radicals are natural, and the body usually neutralizes them by producing antioxidants. But when free radicals outnumber antioxidants, oxidative stress occurs.

Oxidative stress can lead to widespread inflammation, fatigue, headaches, and more. This wear-and-tear on the body can speed up aging.

Metabolism, Molecules, and Aging

Cellular metabolism is measured by certain energy molecules and regulators. Namely, the molecules adenosine monophosphate (AMP), adenosine diphosphate (ADP), adenosine triphosphate (ATP) and AMPK are involved. 

Adenosine monophosphate activated protein kinase (AMPK) is very important to health and healthy aging.

Nutrient sensing pathways are a major class of conserved (evolutionarily) lifespan regulators. Calorie restriction, insulin, insulin-like growth factor signaling and target of rapamycin (TOR) signaling are important nutrient sensing pathways and molecules.

It is important to maintain adenosine nucleotide derivatives (AMP, ADP, ATP and AMPK) at constant levels for longevity. AMP:ATP ratios seem especially predictive for longevity of your cells, which translates into your overall longevity. 

For example, AMPK is the most important regulator of metabolic homeostasis, which keeps your body’s processes “in check/in balance.” When homeostasis is weakened, this increases your risk of illness and is responsible for the changes within your body associated with aging. 

AMPK senses the energy levels and then coordinates enzymes and transcription factors to change the metabolism between energy use and energy conservation as needed. AMPK is a highly conserved molecule that is very much associated with longevity.

How Intermittent Fasting Is Anti-Aging

Much evidence is proving that the health-promoting effects of time-controlled feeding and intermittent fasting can be reproduced with certain medications, supplements and specific dietary restrictions. 

Protein restriction, methionine restriction and even alternate day fasting have helped.

To regulate lifespan and healthspan, attention must be paid to the balance of nutrients within your diet. 

Fasting alone isn’t going to improve your health, if you aren’t giving your body the essential vitamins and minerals it needs to functions when you break your fast.

 

If you and your doctor decide that intermittent fasting is right for you, it’s important to eat a diet that is filled with healthy, whole foods – like the Mediterranean diet.

Click below to read all of our best anti-aging tips:

ABOUT THE AUTHOR

Dr. Meredith Warner is the creator of Well Theory and The Healing Sole. She is a board-certified Orthopedic Surgeon and Air Force Veteran.

She is on a mission to disrupt traditional medicine practices and promote betterment physically, spiritually and mentally to many more people. She advocates for wellness and functional health over big pharma so more people can age vibrantly with more function and less pain.

At Well Theory, Our surgeon-designed products are FDA Registered and formulated to help people:

  • Manage the symptoms of musculoskeletal pain
  • Recover vibrantly from orthopedic related surgeries
  • Fill the gaps in our daily diets
  • Manage pain associated with inflammation

[Webinar] What Is Oxidative Stress?

[Webinar] What Is Oxidative Stress?

In this webinar hosted by Dr. Meredith Warner’s clinic, Warner Orthopedics & Wellness, Dr. Warner talked about the effects of oxidative stress on the body, like fatigue, restlessness, inflammation, brain fog, and more.

Oxidation is what happens when your body metabolizes oxygen to use in its natural processes – such as converting oxygen to energy, when your body is fighting off infection, etc. 

A large body of medical and scientific research has linked oxidative stress to the development of certain conditions – such as cancer, heart disease, and diabetes.

Make sure to watch our video to hear Dr. Meredith Warner break down the basics of oxidative stress, as well as help you find natural solutions to relieving it.

Find Oxidative Stress Relief With Well Theory

These Well Theory products are designed by Dr. Meredith Warner herself for your wellness! Each product incorporates powerful, natural ingredients for pain and inflammation relief.

And most of these products are packed with antioxidants as well:

Tart cherries have an abundance of anthocyanins and flavanols. These are the antioxidant compounds within highly-pigmented fruits and vegetables.

These compounds allow tart cherries to reduce inflammation and decrease oxidative stress in the brain and throughout the body.

This Joint Health Multi is designed to reduce pain and inflammation in joints.

Its natural ingredients, like Turmeric, PEA, and Ginger are not only powerful pain relievers – they also give you a powerful antioxidant boost, which protects your joints from damaging free radicals.

ALA is what is known as a “universal antioxidant,” meaning that it can target free radicals throughout most cells in your body.

It also stimulates the production of your body’s own antioxidants and promotes healthier mitochondrial function, so your cells work more effectively while unencumbered by harmful oxidative stress.

At Well Theory, we strive to give you all the tools you need to take charge of your own health journey. 

ABOUT THE AUTHOR

Dr. Meredith Warner is the creator of Well Theory and The Healing Sole. She is a board-certified Orthopedic Surgeon and Air Force Veteran.

She is on a mission to disrupt traditional medicine practices and promote betterment physically, spiritually and mentally to many more people. She advocates for wellness and functional health over big pharma so more people can age vibrantly with more function and less pain.

At Well Theory, Our surgeon-designed products are FDA Registered and formulated to help people:

  • Manage the symptoms of musculoskeletal pain
  • Recover vibrantly from orthopedic related surgeries
  • Fill the gaps in our daily diets
  • Manage pain associated with inflammation

Surgeon Formulated
For Your Peace of Mind

Natural Ingredients + Cutting-Edge Medical Breakthroughs.

100% NATURAL PAIN RELIEF FOR PEOPLE WORLDWIDE

[VIDEO] How CBD Can Support Your Brain Health

[VIDEO] How CBD Can Help Support Your Brain Health

Supporting your brain health isn’t often something we think about as we age – but we should. One of the first things to deteriorate as we get older is our memory and concentration.

CBD has many powerful health benefits – and can even help support your brain function.

IT’S EASY TO GET STUCK IN OLD WAYS OF LIVING. IT’S TIME TO MAKE ROOM FOR THE NEW WAYS OF HEALING.

A Convenient, Pure Source For Daily CBD Supplementation

Dr. Meredith Warner’s new Hemp-Derived Full Spectrum CBD Softgels are easy to ingest (tasteless) and dissolve quickly to speed absorption into the body.

Our CBD Softgel is rich in terpenes, vitamins, antioxidants, minerals, and omega fatty acids like Omega 3 & 6. We are pleased to offer you a premium source of Full Spectrum CBD Oil.

Meet Your Daily Nutrition Needs – With An Added Anti-Inflammatory Boost!

The ingredients within this CBD Multivitamin work together to benefit the body’s natural systems of healing for pain relief, reduced inflammation, and improved overall wellness.

This multi contains full spectrum hemp-derived CBD which engages with your endocannabinoid system to lower inflammation throughout your body, nervous system, and brain.

Natural Anti-Aging Routine

Natural Anti-Aging Routine

When you think of an anti-aging routine, your mind probably goes to a cosmetics routine centered on aesthetic wellness.

While there’s nothing wrong with wanting to look and feel your best, most anti-aging routines out there miss the mark on helping you age well both inside and out. 

Feeling beautiful is extremely important for most people as it pertains to becoming healthy and this is an important component to overall wellness. But the health and wellbeing of skin is linked to your internal health and wellbeing as well.

At Well Theory, our goal is to help you increase the duration and quality of your “healthspan.” We don’t want you to just have a long life - our goal is to give you the tools and resources you need to curate a long life that is also lived well.

Here are our best tips for improving your overall wellness, so you can enjoy a vibrant lifestyle for many years to come:

Maintain Your Function

As we age, conditions like osteoarthritis, caused by time-related wear and tear on joints, can arise. While there is no known cure (as of yet) for arthritis, you can slow its progression, and manage your symptoms without heavy pharmaceuticals or painful injections that only provide short-term relief. 

Movement has been shown over and over again to promote healthy cartilage and to improve symptoms related to arthritis.

One of the best forms of exercise to incorporate into your daily life is a well-rounded yoga routine. This allows for joint movement and provides resistance at the same time. This way, the joints remain strong and flexible.

Yoga is also a proven way to improve strength, conditioning and flexibility as well as endurance. Yoga has been shown to promote the growth and maintenance of bone.

In addition, yoga is also very good at producing peace of mind, tranquility, and reducing stress and chronic pain. Yoga provides you a way to retrain your body’s pain pathways and to reduce the amount of pain you may feel. It seems that most of this work is done by stimulating the parasympathetic pathway to become more balanced with the sympathetic pathway via the vagus nerve.

Yoga involves some poses that improve balance, which is especially important as we age.

Read more: Why Yoga Is Beneficial At Any Age Or Ability 

And when you’re done practicing, it’s always a good idea to have a recovery plan in place. Go on a short walk afterwards to feel the changes in your flexibility. Make sure you stay hydrated. 

And incorporate naturally antioxidant and anti-inflammatory foods and supplements into your recovery plan as well – so you won’t wake up sore the next day and can keep up with your routine.

Prioritize Diet And Rest

Most of us are dealing with inflammation – and we don’t even know it. Low levels of chronic inflammation may not result in pain you can feel or swelling you can see – but can create wear and tear on your body.

Prioritize eating anti-inflammatory foods, like fruits and vegetables, whole grains, and only small amounts of red meat. Include anti-inflammatory and antioxidant fats like olive oils and essential Omega-3’s like those found in fish.

Click below to read our best anti-inflammatory tips:

Fill The Gaps With Antioxidant And Anti-Aging Supplements

An essential part of your anti-aging routine should be having a plan in place to combat the effects of oxidative stress. 

Aging is a process characterized by the progressive loss of tissue and organ function. The oxidative stress theory of aging is based on the hypothesis that age-associated functional losses are due to the accumulation of ROS-induced damages. (this is damage caused by reactive oxygen species). At the same time, oxidative stress is involved in several age-related conditions (ie, cardiovascular diseases [CVDs], chronic obstructive pulmonary disease, chronic kidney disease, neurodegenerative diseases, and cancer), including sarcopenia and frailty.” 

The reactive oxygen species made by cellular metabolism and from outside insults like toxins https://www.youtube.com/watch?v=tBhExCuFdxs

Get ahead of the curve with our best anti-aging supplements. These are targeted to reduce the effects of oxidative stress and chronic low-grade inflammation. Our Immune Boost Multi contains clinically high doses of vitamins D and C, which many of us are lacking in our diets. As you age, your body may absorb nutrients less efficiently – so increasing your intake is recommended.

Pair this with our Nervous System Multi. This multi contains anti-aging ingredients like chlorella, luteolin, and resveratrol. 

Resveratrol in particular has been shown to have several key anti-aging benefits due to its high antioxidant content. It has been linked to slowing the progression of Alzheimers, improving the health of neural tissues, promoting cardiovascular health, and so much more. 

ABOUT THE AUTHOR

Dr. Meredith Warner is the creator of Well Theory and The Healing Sole. She is a board-certified Orthopedic Surgeon and Air Force Veteran.

She is on a mission to disrupt traditional medicine practices and promote betterment physically, spiritually and mentally to many more people. She advocates for wellness and functional health over big pharma so more people can age vibrantly with more function and less pain.

At Well Theory, Our surgeon-designed products are FDA Registered and formulated to help people:

  • Manage the symptoms of musculoskeletal pain
  • Recover vibrantly from orthopedic related surgeries
  • Fill the gaps in our daily diets
  • Manage pain associated with inflammation

How Aging Impacts The Immune System

How Aging Impacts The Immune System

As we get older, many of our bodily functions begin to slow down or become less efficient. Joint mobility, vitamin absorption, bone and wound healing, and more are all affected. But perhaps the most important function that can be impacted is immunity.

“The effects of aging on the immune system are manifest at multiple levels that include reduced production of B and T cells in bone marrow and thymus and diminished function of mature lymphocytes in secondary lymphoid tissues. As a result, elderly individuals do not respond to immune challenges as robustly as the young.” 

The true causes of altered immunity with ageing have not been fully described. However, accumulation of cellular damage from oxidative stress and the lack of essential vitamins and micronutrients seem to play a very large role.

What Does The Immune System Do?

Your immune system doesn’t just protect you from outside invaders. That’s it’s most well-known and one of the most important functions, but your immune system handles much more than that.

There are two main parts of the immune system: the innate immune system (which you’re born with) and your adaptive immune system, which you develop over time as your body is exposed to viruses, illness, or other microbes.

The innate immune system is a “rapid response” system. It patrols the body and is the first to respond once it finds an invader. It immediately engulfs the invader, and whatever virus or infection is present is killed within these immune system cells (phagocytes.)

The acquired immune system produces antibodies that protect your body from specific types of illness and infection. Antibodies are literally that. They are proteins that act against another protein. 

The lymphocyte will recognize a protein from a virus or bacteria and that protein recognition triggers the production of antibodies against that protein and thus that pathogen. This is the basis of our immune systems that we begin building as we drink our mothers’ milk. 

When you get a vaccine, your body is learning about a virus and producing specific antibodies to protect you from it. A vaccine merely utilizes existing machinery of the natural immunity you are capable of producing.

Dr. Meredith Warner is a board-certified orthopedic surgeon with a thriving private practice in Louisiana, USA. Her practice allows her the freedom to treat patients in the best way possible – on an individual basis. It has always been her goal to seek non-operative treatment and functional recovery over surgical or heavy pharmaceutical means of healing. 

This is why Dr. Warner developed her Bone & Joint Multivitamin. This proprietary blend contains the essential vitamins and minerals she recommends for her patients’ pre- and post-op regimens. She handpicked each ingredient in this Multi to boost musculoskeletal health, help reduce joint + muscle inflammation, and promote full-body wellness.

Four Functions Of The Immune System

  1. Fighting off pathogens. Your immune system fights off bacteria, germs, and viruses you come into contact with every day in the manner described above.
  2. Fighting and removing toxins. Your immune system is responsible for fighting off dangerous substances you come into contact with in your environment. This means that your body is involved in producing antioxidants, which help neutralize free radicals. Often, free radicals (reactive oxygen species) form as a result of a toxic insult to cells.
  3. Fighting off abnormal changes in your body. For example, your immune system is involved in fighting off malignant proliferation of cells that can lead to cancer. The immune system plays an important role in maintaining healthy dynamics of cell death and regeneration in order to maintain your health.
  4. Managing and allowing us to heal after injury. The innate immune system is involved with cleaning up debris such as dead or damaged cells. The immune system as a whole is heavily involved in the healing process for all of our systems after an injury.

How To Support Your Immune System’s Health

One of the best ways to support immunity is to ensure you’re getting the right nutrition, with the correct amount of vitamins – and to avoid inflammatory foods in your diet (like processed foods, simple carbohydrates, excess sugar, and more.)

Unfortunately, many of us aren’t getting the essential vitamins and minerals we need to protect our healthspan (the amount of years we live healthy, vibrant lifestyles.) That’s where supplementation can provide powerful benefits. Healthspan is heavily dependent upon the longevity of the immune system of course.

The Immune Boost Multi

Our Immune Boost Multi is formulated with clinically high doses of vitamins D and C to support your immune system’s function. This multi provides essential nutrients your body needs to function properly to regulate its own inflammatory/immune response – and contains a plant-based phytochemical ingredient to provide a powerful antioxidant punch.

Quercetin is a phytonutrient that is highly antioxidant. The group of phytonutrients it’s part of is known for being potent anti-inflammatories and antioxidants that may exert modulating effects on the immune system.

The antioxidant properties of quercetin can help safeguard your cardiovascular health, and bolster your defenses against “lifestyle” diseases like diabetes and certain cancers. Quercetin itself functions to neutralize reactive electrons attached to molecules – so called ‘free radicals’. This is one of the main ways it acts to protect us.

Also, this study found that “short-term high doses of quercetin and resveratrol alters aging markers in human kidney cells.” 

Our surgeon-formulated Immune Boost Multi is ideal for those looking to optimize their immune function, boost respiratory health, decrease cardiovascular strain, and more.

ABOUT THE AUTHOR

Dr. Meredith Warner is the creator of Well Theory and The Healing Sole. She is a board-certified Orthopedic Surgeon and Air Force Veteran.

She is on a mission to disrupt traditional medicine practices and promote betterment physically, spiritually and mentally to many more people. She advocates for wellness and functional health over big pharma so more people can age vibrantly with more function and less pain.

At Well Theory, Our surgeon-designed products are FDA Registered and formulated to help people:

  • Manage the symptoms of musculoskeletal pain
  • Recover vibrantly from orthopedic related surgeries
  • Fill the gaps in our daily diets
  • Manage pain associated with inflammation