Common Interactions with Well Theory Supplements

Common Interactions With Well Theory Supplements

About ¼ of Americans that take prescription pharmaceuticals also take supplements. Somewhere between 40% and 60% of those with chronic diseases do as well. Side-effects of natural products are exceedingly rare, however many people wonder if the natural product will interfere with the prescription medication.

How Our BODIES Process MEDICATIONS AND HERBAL SUPPLEMENTS

Prescriptions are generally processed in the liver in humans. Certain enzymes within the liver are responsible for breaking apart the drug and then allowing the biologic effects to take place.  

Interactions between an herb or extract and a drug usually occur as a pharmacokinetic interaction; this means the processing rates of each are changed. 

If the rate of processing in the liver changes, then the level of the drug and its effectiveness could also be changed. 

In order to change the pharmacokinetics of a given pharmaceutical, the herb must change the absorption, distribution, metabolism and excretion of the drug.

How Pharmacodynamics Are Changed

Occasionally, an herb or extract might directly interfere with the way a drug works. This is called a change in the pharmacodynamics.

Most of the drug-processing in the liver uses enzymes in the cytochrome P450 super family. In fact, about 80% of all manufactured drugs use these enzymes. 

There are 6 that are considered common. These are the following:

  • CYP1A2
  • CYP2C9
  • CYP2C19
  • CYP2D6
  • CYP2E1
  • CYP3A4

Of these, CYP2D6 and CYP3A4 are responsible for almost 50% of all drugs. If you know what enzyme is primarily utilized by your medication, then you can assess the herbal interaction with that given enzyme – if they use the same enzyme.

Drug Interactions

with Anticoagulants

Of all medications, people most commonly ask about the interaction of herbs and extracts with anticoagulants.

Warfarin

Warfarin is still the most commonly prescribed anticoagulant globally. This is a Vitamin K antagonist. For those on Warfarin, a very tight range of serum levels are needed for effectiveness. The CYP2C9 enzyme is heavily involved in the metabolism of Warfarin. Most interactions with Warfarin involve other prescription drugs, or OTC drugs.

Some herbal remedies are known to act on the CYP2C9 system in the lab, but clinically there is no issue. No food or nutrient has been shown to strongly interact with Warfarin (unless it contains Vitamin K). Soybeans hold a lot of vitamin K. There is a potential interaction with grapefruit due to the furanocoumarins.

There is one reported case of an interaction with a woman on Warfarin who consumed large amounts of chamomile too; this was due to CYP1A2, 3A4 and maybe 2C9. There is a clinically significant reaction of mango and Warfarin due to the inhibition of CYP2C19 by retinol found in the mango.

St. John’s wort will reduce the effectiveness of Warfarin.

Thrombin And Factor Xa Inhibitors

Direct oral anticoagulants are another class of medications to thin the blood. These include thrombin and Factor Xa inhibitors. 

There is no direct evidence of food or herbal interaction here. However, it is wise to discuss herbs such as St. John’s wort with your physician of course. 

Most direct factor Xa inhibitors are processed by the CYP3A4 enzyme.  Some supplements increase levels of medication in the blood, while others will reduce the levels. The same is true for direct thrombin inhibitors.   

Herbs Known To React With Medications

Two herbs are known to have clinically relevant interactions with prescription and OTC medications; these are St John’s Wort and Goldenseal.

There is one study that showed an effect of curcumin on CYP1A2 (it induced enzyme activity). This could make it interact with antidepressants or antipsychotics. It may also interact with the 3A4 enzyme.

Most physicians become concerned when a patient is on chemotherapeutics; in this case, as always, you should check with the prescribing physician.

Both cinnamon and turmeric are thought to increase anticoagulation a bit as well. Many people on Warfarin avoid turmeric due to the increase in bleeding potential.

Of course, many people on anticoagulants still take aspirin or NSAIDs daily. These definitely cause problems with prescription anticoagulants; these problems are more clinically relevant than any due to a plant or herb.

Herbal Supplements Compared To

eating or drinking herbs

The risks inherent to supplements are the same risks inherent to eating or drinking the same plants.

For example, there is a case report of a man on dabigatran who was hospitalized for bleeding after consuming a mixture of boiled cinnamon and ginger.  In fact, herbal teas are the most commonly consumed supplement by those on such anticoagulants.

If you are on a direct thrombin or Factor Xa inhibitor ask your physician about the following herbs and see what dose they might recommend: danshen, dong quai, ginseng, ginger, gingko biloba, green and chamomile tease, St. John’s wort, turmeric.  

Do Fruit And Berry Supplements

interact with prescriptions?

Brightly colored fruits and berries have abundant amounts of phytochemicals and antioxidant power.

For example, tart cherry extract holds anthocyanidins and these allow the extract to provide excellent pain relief and strong antioxidant benefits.

In general, the effect of plant phytochemicals such as anthocyanidins, proanthocyanidins and phenolic acids is much weaker on liver enzymes than the effect of grapefruit (furanocoumarins).  Berries and berry extracts are poor inhibitors of liver enzymes. They have little to no effect on most drugs.

Consult With Your Treating Physician

For surgery that requires anesthesia, one rule of thumb is to stop herbal remedies about 5 days prior to the procedure. This will ensure there are no interactions with the agents used for sleep and pain control during surgery.

If you have a concern, we always recommend that you consult the treating physician. However, most American-trained physicians will likely have no idea how to answer the question.

There are resources available to the public. These include the NIH Office of Dietary Supplements, the NIH National Center for Complementary and Integrative Health, and information on the Memorial Sloan Kettering Cancer Center’s website.

ABOUT THE AUTHOR

Dr. Meredith Warner is the creator of Well Theory and The Healing Sole. She is a board-certified Orthopedic Surgeon and Air Force Veteran.

She is on a mission to disrupt traditional medicine practices and promote betterment physically, spiritually and mentally to many more people. She advocates for wellness and functional health over big pharma so more people can age vibrantly with more function and less pain.

At Well Theory, Our surgeon-designed products are FDA Registered and formulated to help people:

  • Manage the symptoms of musculoskeletal pain
  • Recover vibrantly from orthopedic related surgeries
  • Fill the gaps in our daily diets
  • Manage pain associated with inflammation

CBD and Brain Health

CBD And Brain Health

CBD And Your Brain Health

how CBD affects the endocannabinoid system

Did you know that CBD can improve your brain health? No? Well CBD molecules are attracted to receptors in your brain that can protect brain cells, and reduce anxiety, depression, stress, and even sleep!

The Endocannabinoid System

& how CBD uses it to improve brain health

Are you familiar with the Endocannabinoid system? You might not be.

The Endocannabinoid system is a collection of receptors and ligands (messengers that attach to the receptors) and enzymes in your nervous system and body. 

Basically, it interacts with phytocannabinoids (plant-based cannabinoids) and endocannabinoids (human-based cannabinoids) that naturally occur in your body. The ECS functions to maintain homeostasis or balance.

CBD molecules attach to or modify the activity of the CB1 and CB2 protein receptors in your body. CB1 receptors are located in the central nervous system, inside the brain, and affect functions such as coordination, pain, emotions, and appetite. 

CB2 receptors are found throughout the peripheral nervous system and on many cells in the immune system that affect inflammation and pain responses.

Taking CBD can help regulate these responses to reduce anxiety, depression, inflammation, and pain naturally with fewer side effects. 

CBD is just a phytocannabinoid that exerts its effects on natural receptors of the ECS in the brain and body.

What Do We Mean By Improving Brain Health?

CBD is able to assist in reducing neuroinflammation, reducing oxidative stress, reducing excitotoxicity, promoting neurogenesis, and improving amygdala activity. These are some of the reasons it helps with brain health:

  • Neuroinflammation is linked to conditions such as depression, anxiety, Alzheimer’s disease, stroke, and epilepsy.
  • Oxidative stress occurs with natural free radical aging and can result in neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease.
  • Excitotoxicity is a natural process of cell death triggered by overstimulated cell receptors that are related to stroke, traumatic brain injuries, and neurodegenerative diseases.
  • Neurogenesis is the process of new brain cell growth with the potential to positively affect memory, mood, and other cognitive functions.
  • Amygdala is a small section in the brain that processes emotions.

Should You Take CBD To Improve Your Brain Health?

You can also improve your brain health by taking Alpha-lipoic acid! ALA exists in the mitochondria in your cells in small amounts – and when taken as a supplement, supports oxidative health in the brain and throughout your entire nervous system.

ABOUT THE AUTHOR

Dr. Meredith Warner is the creator of Well Theory and The Healing Sole. She is a board-certified Orthopedic Surgeon and Air Force Veteran.

She is on a mission to disrupt traditional medicine practices and promote betterment physically, spiritually and mentally to many more people. She advocates for wellness and functional health over big pharma so more people can age vibrantly with more function and less pain.

At Well Theory, Our surgeon-designed products are FDA Registered and formulated to help people:

  • Manage the symptoms of musculoskeletal pain
  • Recover vibrantly from orthopedic related surgeries
  • Fill the gaps in our daily diets
  • Manage pain associated with inflammation

Surgeon Formulated
For Your Peace of Mind

Natural Ingredients + Cutting-Edge Medical Breakthroughs.

100% NATURAL PAIN RELIEF FOR PEOPLE WORLDWIDE

How Topical CBD Products Work

How Topical CBD Products Work

CBD isn’t only available as supplements in pills and oil form. CBD products are also offered in a variety of topical creams and lotions! 

CBD is just as effective when applied topically as it is when taken orally. The vehicle for CBD simply depends upon your precise needs.

Understanding The Science Behind CBD

Cannabidiol, more commonly referred to as CBD, is a derivative of the Cannabis sativa plant. CBD is the non-psychoactive compound found in the plant. 

CBD products on the market are allowed to have 0.3% (trace amounts) of tetrahydrocannabinol (THC), the psychoactive compound in the plant, to comply with legislation. Most CBD isolate products have absolutely no THC.

Topical Application: How It Works

CBD taken orally and topically has anti-inflammatory, antioxidant and properties that reduce discomfort. Since CBD can penetrate the dermal and subdermal layers of the skin if combined with appropriate carrier oils and/or plant-based carriers, many people will gravitate towards topical applications of CBD for convenience and targeted applications. 

There is also a thought that there are false positives during drug screenings occasionally with some oral products (if not third-party certified). Such possibilities are rarer for topical CBD products as any present THC is unlikely to reach the bloodstream. 

That being said, if your product is from a USDA-regulated hemp crop then there is no legal way that there will be more than 0.3% regardless. All of our products are made with CBD extracted from the Industrial Hemp plant and fall within this range.

Read More: Which Well Theory Topical Cream Is Right For You

When the CBD is absorbed into the skin it begins interacting with the Endocannabinoid System. 

This system has receptors that run through the entire body that help regulate homeostasis and controls things like hunger, mood, inflammation, etc.

CBD binds with the CB1 and CB2 receptors, among others, of this system to mitigate discomfort, the ravages of aging and oxidation and inflammation.

Ready To Give Topical CBD A Try?

Dr. Meredith Warner, Orthopedic Surgeon and founder of Well Theory specially formulated her CBD Pain Relief Cream to offer quick relief with pure CBD, lidocaine, and menthol. As a bonus it naturally moisturizes the skin with aloe vera! 

This product has a curated blend of healthy and beneficial phytochemicals from specific essential oils known to assist in the recovery from oxidative stress and chronic inflammation.

ABOUT THE AUTHOR

Dr. Meredith Warner is the creator of Well Theory and The Healing Sole. She is a board-certified Orthopedic Surgeon and Air Force Veteran.

She is on a mission to disrupt traditional medicine practices and promote betterment physically, spiritually and mentally to many more people. She advocates for wellness and functional health over big pharma so more people can age vibrantly with more function and less pain.

At Well Theory, Our surgeon-designed products are FDA Registered and formulated to help people:

  • Manage the symptoms of musculoskeletal pain
  • Recover vibrantly from orthopedic related surgeries
  • Fill the gaps in our daily diets
  • Manage pain associated with inflammation

Surgeon Formulated
For Your Peace of Mind

Natural Ingredients + Cutting-Edge Medical Breakthroughs.

100% NATURAL PAIN RELIEF FOR PEOPLE WORLDWIDE

Microdosing: The Best Way to Start Taking CBD?

Microdosing: The Best Way to Start Taking CBD?

Microdosing:

how to do it, and why you should

CBD, otherwise known as Cannabidiol, is just one therapeutic cannabinoid found in cannabis and the industrial hemp plant. 

While CBD is largely found to be safe at low and high doses, the science surrounding its effects is new. Your dosage amount is going to be a subjective experience, and that makes it tough to know where to begin. 

This is why microdosing, especially when you’re first starting out with CBD, is a great way to get started.

What is Microdosing?

and how to do it

Essentially, microdosing involves taking small amounts of CBD on a regular schedule and documenting the effects. It’s perfect for beginners and ideal for those who are looking to “reset” their endocannabinoid system to return to a smaller therapeutic dose. 

Over time, it is perhaps possible to develop a tolerance to CBD (this is being studied), so microdosing is a great way to overcome that obstacle.

For beginners, microdosing helps you understand the effects CBD has on your body – and if you need a higher or lower dose. Microdosing is a tool you can use to find your optimal dosage range, the optimal time of day to take CBD, and more.

Read More: Why Does CBD Work So Well?

Microdosing is actually being used with psychedelic medications like LSD and mushrooms now to treat depression and anxiety. This is a known and beneficial way to get natural remedies into your system safely.

How to Start Microdosing

creating a personalized schedule

Below is a sample schedule that you can try, but remember – adapt it to your routines. If you have never taken CBD before, it may be best to start off trying CBD right before bed, or microdosing during a weekend where you don’t have to be at work. Use your intuition to guide you as you create your own microdosing regimen.

You can use our CBD Oil Tincture to develop your regimen. It has a dropper that makes microdosing easy! 

You can control how many drops are released by gently depressing the rubber tip of the dropper. We recommend dropping CBD oil directly into your mouth for quicker absorption.

7 AM
1 drop on an empty stomach.
8 AM
2 drops with morning tea or coffee.
9 AM
3 drops with a light breakfast.
10 AM
4 drops with a tall glass of water.
11 AM
5 drops with an early lunch or protein-packed snack, like a handful of almonds.

Right before you take the next dose, write down any symptoms you experienced over the last hour. Sometimes, drowsiness is not uncommon. 

If you had a headache, is it gone now? Is any muscle soreness diminished? Here are some good questions to ask yourself:

  • On a scale of 1-10, how is your anxiety level?
  • On a scale of 1-10, what is your pain level?
  • On a scale of 1-10, how comfortable/relaxed are you?

Feel free to add more questions depending on the intent behind your new CBD routine. If you wanted to relieve stress in the middle of a workday, compare notes from multiple days of microdosing and see if your mood has improved. 

Of course, to really know the effects of CBD you need to keep the same sort of journal for a month or so before beginning this natural treatment to know what your baseline symptoms and side effects are.

After one morning of microdosing, you’ll have taken a little over half of a full serving of our CBD oil tincture. 

 

If you don’t feel any effects, continue to add more drops every hour until you reach the end of the day.

This should give you a good idea of how much – half a dropper, or a full dropper, or somewhere in between – you need for optimal results. You can also start with our CBD Softgels for a standard dose each day!

What Happens after Microdosing?

develop your routine

Microdosing is a great short-term solution for finding your optimal dose. However, once you find it, you can begin to take CBD in the dose you’ve determined is best for you. From there, you can take that amount once, twice, or even three times a day, and slowly increase your dose as needed.

A lot of people find that they can handle 1-2 servings a day, aka, 1-2 dropperfuls. You may need more than that, and that’s okay. This process is all about finding the correct dose for you.

Once you get used to CBD and know that you won’t have any adverse effects, you can take it in the morning in lemon water, mid-afternoon during your lunch break, or at home when you’re winding down for the evening. 

You can also take it as-needed to reduce inflammation and soreness after exercise, relieve anxiety or stress, or right as you’re going to bed for restful sleep.

 

ABOUT THE AUTHOR

Dr. Meredith Warner is the creator of Well Theory and The Healing Sole. She is a board-certified Orthopedic Surgeon and Air Force Veteran.

She is on a mission to disrupt traditional medicine practices and promote betterment physically, spiritually and mentally to many more people. She advocates for wellness and functional health over big pharma so more people can age vibrantly with more function and less pain.

At Well Theory, Our surgeon-designed products are FDA Registered and formulated to help people:

  • Manage the symptoms of musculoskeletal pain
  • Recover vibrantly from orthopedic related surgeries
  • Fill the gaps in our daily diets
  • Manage pain associated with inflammation

Surgeon Formulated
For Your Peace of Mind

Natural Ingredients + Cutting-Edge Medical Breakthroughs.

100% NATURAL PAIN RELIEF FOR PEOPLE WORLDWIDE

3 Ways To Start Using CBD Oil Daily

3 Ways To Start Using CBD Oil Daily

At Well Theory, we offer a variety of CBD products for your use! CBD is a powerful and natural anti-inflammatory, antioxidant, stress reliever – and so much more. This is why we offer topical creams, supplements, and more to give you plenty of options to include CBD into your daily wellness routines!

One of our favorite products is our CBD Oil Tincture. This tincture includes Broad Spectrum CBD and MCT Coconut Oil. This tincture is tasteless, and because it contains broad-spectrum CBD, gives you an opportunity to enjoy the benefits of all the beneficial cannabinoids and terpenes the hemp plant has to offer – with no THC.

Here are 3 ways you can start using our CBD Oil Tincture on a daily basis!

Sublingual Dosing

Our primary recommendation for taking this CBD Oil is through sublingual dosing. This means taking it under the tongue. Dosing CBD oil this way allows your body to absorb the CBD faster.

This type of dosing allows the hemp-derived CBD to quickly enter the bloodstream - where it exerts its anti-inflammatory and balancing effects by engaging the endocannabinoid system.

The endocannabinoid system is your body’s regulatory system. In fact, receptors for this important system are found throughout the body. It is in charge of telling your body when to produce inflammation, pain, hunger pangs, stress, and more. 

CBD binds to certain receptors throughout this system to calm inflammation, reduce tension, improve sleep, and promote overall balance.

Infuse It In Drinks

Our CBD Oil is tasteless, so it can be added to virtually any drink you want! Add it to iced teas or coffees, citrus-based drinks, and more. If you’re trying to increase your water intake, why not add a few drops of CBD oil to your water bottle for an added anti-inflammatory boost? 

In some jurisdictions, CBD-infused beverages are available commercially!

We do not recommend adding it to hot drinks, like freshly brewed coffee, as CBD may lose some of its benefits when exposed to high temperatures.

Add It To Food

CBD Oil makes a great addition to your go-to salad dressings, pesto, and more. Remember – you don’t want to expose CBD oil to high heat, but you can add it to anything that’s room temperature.

CBD is an excellent addition to a morning smoothie or fresh-squeezed juice! Be sure to blend well so that it incorporates properly.

ABOUT THE AUTHOR

Dr. Meredith Warner is the creator of Well Theory and The Healing Sole. She is a board-certified Orthopedic Surgeon and Air Force Veteran.

She is on a mission to disrupt traditional medicine practices and promote betterment physically, spiritually and mentally to many more people. She advocates for wellness and functional health over big pharma so more people can age vibrantly with more function and less pain.

At Well Theory, Our surgeon-designed products are FDA Registered and formulated to help people:

  • Manage the symptoms of musculoskeletal pain
  • Recover vibrantly from orthopedic related surgeries
  • Fill the gaps in our daily diets
  • Manage pain associated with inflammation

Surgeon Formulated
For Your Peace of Mind

Natural Ingredients + Cutting-Edge Medical Breakthroughs.

100% NATURAL PAIN RELIEF FOR PEOPLE WORLDWIDE

How Quickly Is CBD Oil Effective?

How Quickly Is CBD Oil Effective?

incredible power of cbd

Here's what you need to know

Hemp-derived CBD oil has become a popular supplement due to its effectiveness at alleviating pain and for its mood-boosting capabilities. With a variety of forms to choose from, how do you know the right type and dosage for you to find the fastest results?

Follow these pointers when searching for the right CBD product for you.

What Forms of CBD

can you take?

There are many ways that cannabidiol can be consumed. With a long list of products on the market, how can you know what will truly be effective to relieve your pain?

The form of Hemp that you choose depends on the condition you are looking to treat. Topical CBD , which includes balms, creams, sprays, and patches, are absorbed through the dermal layers of the skin and are best for targeting muscle pain and soreness or joint inflammation. 

For headaches or anxiety treatment, hemp-derived CBD may be consumed orally through oil, capsule, and softgel supplements.

Make sure to consult with your personal physician if you have any questions about the right forms of CBD for you. The form, dosage, and other factors are important with regard to condition support and a physician is a good source of general medical knowledge.

How quickly is it effective?

For the treatment of pain such as headaches and muscle soreness, simply apply a Hemp cream to the affected area or take the specified oral dose of CBD oil. This should take no longer than thirty minutes to an hour to take effect and provide you with relief. The amount and type of relief will be variable, of course.

The speed of effectiveness for CBD can vary from person to person, and it can be affected by both the form of CBD that you take as well as the quality of the product. Your weight, metabolic rate, and body composition also dictate how quickly and easily CBD is broken down within the body.

How Can You Boost

the effectiveness of your CBD?

1. Follow the dosage instructions on the product label.

There are instructions on the bottle of your CBD oil for a reason! Take the full amount of CBD oil indicated. This builds up the amount of CBD in your system. Missing a daily dose or taking less than the specified amount can lower the product’s efficiency.

2. Listen to your body.

Since everyone’s body responds differently to Hemp, you may consider spacing out your Hemp intake throughout your day. For example, if your daily dose is one dropper full once a day, experiment with taking half a dropper twice a day. Although to date we know of no adverse effects of this phytochemical, if you have any sort of bad reaction please stop taking the plant supplement.

3. Look for high-quality products with medical backing.

There are many brands and forms of CBD on the market, but it can be hard to find effective products that you can trust. Do your research beforehand to help you cut out the guesswork.

At Well Theory, we are dedicated to providing you with the highest quality and most effective forms of Hemp to fit into your daily schedule. From supplements to oil and more, we have a product to meet your needs at any point in your day.

ABOUT THE AUTHOR

Dr. Meredith Warner is the creator of Well Theory and The Healing Sole. She is a board-certified Orthopedic Surgeon and Air Force Veteran.

She is on a mission to disrupt traditional medicine practices and promote betterment physically, spiritually and mentally to many more people. She advocates for wellness and functional health over big pharma so more people can age vibrantly with more function and less pain.

At Well Theory, Our surgeon-designed products are FDA Registered and formulated to help people:

  • Manage the symptoms of musculoskeletal pain
  • Recover vibrantly from orthopedic related surgeries
  • Fill the gaps in our daily diets
  • Manage pain associated with inflammation