[VIDEO] Here’s Why You Need To Address Chronic Inflammation

[VIDEO] Here's Why You Need To Address Chronic Inflammation

“In my years of clinical practice, I’ve learned that the root cause of many diseases is unchecked, chronic inflammation.”

Chronic inflammation is also called low-grade inflammation, because it produces low levels of inflammation throughout the body. This may not sound very threatening, but it’s been linked to certain diseases, like heart disease, diabetes, and certain cancer.

If left unchecked, chronic inflammation can hurt your health in the long run.

IT’S EASY TO GET STUCK IN OLD WAYS OF LIVING. IT’S TIME TO MAKE ROOM FOR THE NEW WAYS OF HEALING.

Delta-8 THC Gummy With Full Spectrum CBD

Feel More Relaxed + Pain Relief and Sleep Support

Delta-8 THC and Full Spectrum CBD work synergistically to help you fall asleep faster while promoting deep relaxation, pain relief, and more. Hemp-derived DELTA-8 THC contains neuroprotective properties that may help reduce anxiety, pain, and promote better sleep.

Dr. Warner wanted to offer this product as a more affordable alternative to medical marijuana.

Delta-8 THC Tension + Pain Relief Cream

Extra-Strength THC Cream For Sore Muscles, Arthritis, And Joint Pain

Our new 2oz bottle of Delta-8 topical cream comes packaged in a convenient pump bottle for on-the-go relief that moves with you.

This extra-strength formulation was designed by Dr. Meredith Warner to harness the anti-inflammatory and soothing effects of Delta-8 THC, Turmeric, Arnica, Menthol, and a custom blend of fragrant and soothing Essential Oils.

[VIDEO] The Best Multi Ingredients For Joint Health + Oxidative Stress

[VIDEO] The Best Multi Ingredients For Joint Health + Oxidative Support

This Joint Health Multi does more than relieve pain and inflammation in your joints. It contains highly antioxidant ingredients, like curcumin, to provide powerful antioxidant support throughout your body – not just in the joints.

IT’S EASY TO GET STUCK IN OLD WAYS OF LIVING. IT’S TIME TO MAKE ROOM FOR THE NEW WAYS OF HEALING.

Joint Health Multi

Most Complete Joint Inflammation Formula

Dr. Meredith Warner’s new Joint Health Multi is designed to relieve sore joints while reducing inflammation over time with natural ingredients.

Highly absorbable & unique formulation with clinically studied ingredients to improve joint health, decrease joint discomfort, reduce pain, elevate brain health, and boost energy levels.

Tart Cherry Extract

A Powerhouse Supplement For Muscle Recovery & Inflammation Support

Orthopedic Surgeon Dr. Meredith Warner, LOVES TART CHERRY! She developed these tart cherry supplements for those looking for natural pain relief without NSAIDs and recovery for overused muscles and joints.

Daily Recovery For Joints, Muscles & Inflammation.

[VIDEO] Why Tart Cherry Extract Is Perfect For Inflammation

[VIDEO] Why Tart Cherry Extract Is Perfect For Inflammation

Dr. Meredith Warner is an Orthopedic Surgeon & treats those in pain daily.  She loves to recommend Tart Cherry Extract for those looking to reduce inflammation and pain naturally – a great way to avoid clinical drugs or NSAIDs.

⭐ Help lower inflammation 

⭐ Help recover muscles

⭐ Help improve range of motion 

⭐ Support oxidative stress 

Dr. Meredith Warner is a firm believer in using natural ingredients as a first option for treating pain & inflammation.

IT’S EASY TO GET STUCK IN OLD WAYS OF LIVING. IT’S TIME TO MAKE ROOM FOR THE NEW WAYS OF HEALING.

Tart Cherry Extract

A Powerhouse Supplement For Muscle Recovery & Inflammation Support

Orthopedic Surgeon Dr. Meredith Warner, LOVES TART CHERRY! She developed these tart cherry supplements for those looking for natural pain relief without NSAIDs and recovery for overused muscles and joints.

Daily Recovery For Joints, Muscles & Inflammation.

CoQ10 Plus Gummy

Cell Protection + Muscle Pain Support + Migraine Support + Post Activity Recovery + Heart Health

Fight oxidative stress and enhance energy levels throughout your day with these antioxidant-rich gummies!

This natural formulation gives your body a highly antioxidant boost so it can fight free radical damage. This frees up the mitochondria in your cells to function optimally, increasing mental clarity, reducing bodily inflammation, and improving overall health.

Osteoarthritis Is Inflammatory

Osteoarthritis Is Inflammatory

Yes, osteoarthritis really is inflammatory.

Most medical doctors and other health care providers have been taught for years and years that osteoarthritis (OA) is from wear-and-tear or from trauma. This fits a narrative in our society that damage and problems are always the fault of others. This also fits a narrative in professional schools that does not include anything about nutrition, prevention or overall wellness.

However, the current state of research and the current body of knowledge in basic and clinical science speaks to the completely inflammatory nature of OA. Indeed, the commonly thought reasons for OA are simply offshoots of inflammation.

How Prevalent Is Osteoarthritis

OA is the most common reason for disability worldwide right now.  It is the leading cause of chronic pain in our country and globally. Genetic factors seem to the be one of the strong determinants of suffering from OA.

Studies of identical twins have illustrated this. If one twin works in manual labor and is very active, while the other twin has a desk job and is inactive, their lumbar MRIs look the same. This indicates that ‘wear-and-tear’ is not really the culprit. Likewise, if one twin had trauma (as in a car accident) and another did not, again the MRIs are the same (Spine 2006). This indicates that trauma generally is also not the reason for OA. So what is?

Often, we think OA is an inevitable part of aging. OA must be like wrinkles and grey hair then, correct? However, certain populations around the world have little to no pain and are active well into the 90s and beyond. They do not have nearly the same numbers of joint replacement surgery that we have here.

Many older adults have absolutely no problem with OA at all. The Blue Zone populations complain about arthritis far less than do we, and they live into the 100s on a regular basis. So, arthritis can’t be inevitable and only due to aging then.

Osteoarthritis Is A Cartilage Disease

OA is considered a non-communicable chronic disease; that is, you can’t ‘catch’ OA. OA is basically a disease of damaged cartilage.

Articular (joint) cartilage is made of a very specialized connective tissue. It is comprised of collagen, chondrocytes, an extracellular matrix, smaller proteins like aggrecan, proteoglycan, cartilage oligomatrix protein, glycoproteins, water and fibronectin. There are also biologically active enzymes and cytokines present. Some enzymes function to degrade cartilage, some function in matrix turnover, some will stimulate the chondrocytes to make more cartilage and others manage the inflammatory environment of the joint itself. OA is a disease of the entire joint; it affects the bone, synovium, ligaments, fascia and the cartilage.

Genes associated with tissue metabolism are active for cartilage. Changes in the genes will trigger changes that lead to disorders in the cellular functional pathways. For example, the initiation and progression of OA can cause changes in the nf-kB pathway. This pathway is one of the primary drivers of chronic and low-grade inflammation. Different abnormalities that occur in regulatory proteins and genes lead to cartilage calcification and degradation.

Cartilage disease, like OA, is accompanied by synovitis. Synovitis is the inflammation of the lining of the joint capsule. Each joint has a capsule around it that contains the joint and the joint fluids. The synovial lining releases cytokines and matrix-degenerating enzymes into the joint and this leads to cartilage damage and the synovial cells continue to proliferate and produce even more damaging proteins. This, of course, results in progressive degeneration of the joint and joint tissues. The environment of increased levels of matrix metalloproteinases is responsible for the high level of proinflammatory cytokines that go on to damage the joint.

Today, many drug companies are looking for MMP-blocking agents to stop the cycle of inflammation. Another direction that drug companies are heading is toward blocking the smaller cytokines (IL-1, IL-6) that induce the MMPs to damage the cartilage.

Inflammation Is The Cause

Adipose tissue hormones and synovial products cause intense inflammation and are key to the development of OA. There is a correlation between the presence of inflammatory mediators and the development and progression of OA. It is well-known now that inflammation in the joint tissues is key for the start and progression of arthritis; the levels of inflammation also directly correlate to the levels of pain and dysfunction.  

There are inflammatory markers that can be checked in serum to assess the activity level of the disease process. The overall balance of good and bad cartilage is disturbed in the pro-inflammatory environment of arthritis. There are higher levels of IL-1beta, IL-6, TNF-alpha that have been released by the damaged cartilage cells. These in turn induce more damage to cartilage cells. Worse, the inflammatory environment stops the chondrocytes from producing new matrix and cells as they should.

Joint trauma is often considered the cause of osteoarthritis and joint degeneration. After trauma, generally a surgeon will stabilize the joint. However, studies have shown that the re-stabilization of the joint does not reduce the risk of degeneration. This means that the problem is not the trauma, or even the change in shape or character of the joint.

Human studies have found that inflammatory mediators are very high just after an injury, but they also remain high later as compared to control groups. It has also been discovered that there is a protective role for the hemarthrosis (blood-joint) that forms after injury; this substance produces IL-10 and IL-4, both of which are protective of the joint and are there to counteract the effects of the increased levels of inflammatory proteins. More IL-10 is also found in joint fluids after exercise; it is known that exercise is also protective of joint tissues.

It is thought that in some people, the pro-inflammatory response that occurs just after injury is not controlled late. This is why some go on to form OA but not all do so. The ability to control and manage the inflammatory state of the joint has nothing to do with the trauma of course.

Other Factors That Influence Osteoarthritis

The strongest systemic influence on OA appears to be obesity. Obesity affects both weight-bearing and non-weight-bearing joints, therefore the problem can’t simply be load. Likewise, people of the same height but with more muscle than fat tend to have less arthritis than the counterparts.

The problem with obesity is that adipose tissue produces and promotes inflammation. Inflammatory substances found in the serum of the obese include certain free fatty acids, cytokines, adipokines and reactive oxygen species are very prevalent with obesity. For example, leptin and adiponectin have catabolic and inflammatory influence on cartilage. Likewise, weight loss is known to reduce circulating levels of IL-6 and TNF-alpha. This is true with or without any sort of joint trauma.

Weight loss protects cartilage. The beneficial effects of exercise seen on joints in overfed mice was found to be due to a reduction in inflammatory mediators, not the actual loss of poundage.

Inflammation happens without trauma most of the time. Beside the inflammation caused by the systemic condition of obesity, there are other mechanisms of inflammation and OA.

The body will produce what are known as ‘danger signals’ in the setting of damaged tissues, abnormal proteins or DNA, or infection. For example, the receptor for advanced glycation end products (RAGE) will pick up on the danger signals made by the advanced glycation end products (AGEs). AGEs are damaging proteins caused by oxidative stress, inflammation and hyperglycemia. Likewise, they are consumed in most Americans’ diets on a daily basis. The AGEs actively damage collagen and induce the inflammation associated with OA.

This happens just by living and is not due to any sort of wear-and-tear or traumatic incident. Rather, the danger signals are simply from the levels of chronic inflammation and reactive oxygen species that are prevalent in most modern humans right now.

Adopting An Anti-Inflammatory Diet

Simply eating a more anti-inflammatory diet can have a large effect on the pain and symptoms of arthritis.  A diet does nothing to change and so-called wear-and-tear, nor will a diet reverse any trauma or injury that may have occurred.

This leads one to wonder, how can what I eat modify the pain my joint feels? The answer is that the diet reduces the overall burden of the inflammatory proteins and the reactive oxygen species that are responsible for the pain of arthritis.

Foods found in the Mediterranean diet are high in omega-3 fatty acids, beta carotene, magnesium, fiber and olive oil (omega-9 fatty acids); all of these actively reduce the levels of inflammatory proteins in the body.  

Just two weeks after switching to a plant-based diet, a group of people with painful arthritis had less pain (Arthritis. 2015).  A research group followed 4000 patients for a different study and found that the ones that followed the Mediterranean diet were less likely to develop joint problems (Am S Nut. 2016). This means that arthritis must be caused by far more than simple wear-and-tear of life; it is clear that inflammation is the cause and most likely will be the cure.

ABOUT THE AUTHOR

Dr. Meredith Warner is the creator of Well Theory and The Healing Sole. She is a board-certified Orthopedic Surgeon and Air Force Veteran.

She is on a mission to disrupt traditional medicine practices and promote betterment physically, spiritually and mentally to many more people. She advocates for wellness and functional health over big pharma so more people can age vibrantly with more function and less pain.

At Well Theory, Our surgeon-designed products are FDA Registered and formulated to help people:

  • Manage the symptoms of musculoskeletal pain
  • Recover vibrantly from orthopedic related surgeries
  • Fill the gaps in our daily diets
  • Manage pain associated with inflammation

4 Reasons to Take Gaba Daily

4 Reasons to Take Gaba Daily

Not many people are familiar with GABA. So what is it? GABA or Gamma-aminobutyric acid is a neurotransmitter that helps send messages between the brain and the nervous system.  This nonprotein amino acid is found in almost every prokaryotic (lacks organelles or internal membranes) and eukaryotic (having a nucleus and internal membranes) organism.  It is a large part of the pool of free amino acids actually.  

Gaba is a bioactive compound that may be found in foods. In plants, it acts in the Krebs cycle and helps with energy production. For humans, it is a powerful neural signal transmitter. Gaba has been located within tomatoes, tea, soybeans, brown rice (germinated) and others. Fermented foods are a particularly good source of this vital amino acid product. Even sourdough bread is a great source of GABA.

In mammals, GABA should be found in high concentrations in the brain.  In fact, somewhere between 60% and 75% of the brain synapses are GABAergic.  

Our bodies naturally produce in our brains to reduce nerve cell activity. So why should you be taking GABA daily?

Improves Sleep

GABA has a calming effect and can naturally help induce sleep by making your nerves less excitable.

One study found that when participants were given GABA, they were able to fall asleep faster. Those with insomnia are likely to produce GABA naturally in lower levels.

https://www.ncbi.nlm.nih.gov/pubmed/26052150

GABA helps to protect the neurons from cell death.  This will assist the brain during sleep’s detoxification and clean-up functions.  

One of the side-effects of drugs such as gabapentin is sleepiness.  Gabapentin acts on one of the GABAergic receptors.  Both baclofen and gabapentin have demonstrated the ability to protect neurons from cell death as well.  

Multiple studies have looked at GABA with regard to sleep improvement and the results are very promising.

Reduce Anxiety

Since GABA mainly works to reduce nerve excitability, it has been linked to reducing the feelings of anxiety and fear. Some anxiety disorders have been associated with low levels of GABA.  GABA is effectively a way to tamp down the excitable effects of a different neurotransmitter, glutamate.  GABA has been used to treat problems such as depression and sleeplessness.  Obviously, lack of sleep would enhance the detrimental symptoms of depression and anxiety. 

A study done in the American Journal of Psychiatry found impaired GABA responses in participants with panic disorder, an anxiety disorder defined by recurring panic attacks.

https://pubmed.ncbi.nlm.nih.gov/15569888/

Benzodiazepines, such as Xanax or Valium, strongly bind a certain GABA receptor actually.  The threshold for seizure, anxiety, panic and stress response are all regulated by certain GABA receptors.  Other GABA receptors manage mood, pain and memory.  Scientists believe that most of the effects of GABA on the brain actually happen in the peripheral nervous system.    

High Blood Pressure

GABA supplements are sometimes used as a natural method to lower blood pressure. Poor sleep and sleeping disorders have been known to contribute to higher blood pressure and hypertension.

In one study, participants with borderline high blood pressure were given a chlorella supplement high in GABA. The results of the study showed a significant reduction in blood pressure.

https://pubmed.ncbi.nlm.nih.gov/19811362/

Animal studies have also shown that ingestion of GAGA-rich foods will decrease blood pressure.  GABA-enriched fermented soybean diets lowered blood pressure.  As well GAGA-rich green tea also reduced blood pressure in hypertensive rats.  Similar findings have been seen in human studies as well.  An intervention with fermented milk, holding between 10 to 12mg of GABA, reduced BP in hypertensive adults.  Another study showed that supplementation of just 80mg of GABA reduced BP in adults with (mild) hypertension.  

Reduce Inflammation

Research has found that GABA has the potential to decrease inflammatory responses. GABA is believed to reduce activity in the nerve pathways that trigger joint inflammation.

One study on mice monitored the supplementation of GABA found that the risk of developing arthritis was reduced and symptoms in those that did develop arthritis were less severe.

https://www.ncbi.nlm.nih.gov/pubmed/21604972

GABAergic circuit alterations are associated with neurodegenerative disorders such as Alzheimer’s and Huntington’s along with Parkinson’s and even simple senile dementia.  

GABA traps reactive intermediates (ROS) created during metabolism.  GABA has been able to capture the ROS created during lipid (cell membrane) peroxidation and to increase the activity of human antioxidant enzymes (superoxide dismutase and glutathione peroxidase). 

Have You Checked Out Our New Sleep Gummy?

Our new Restful Sleep Gummies are formulated with Tart Cherry Extract, Melatonin, and GABA to help your body fall asleep faster, stay asleep longer, and wake up feeling refreshed! This formula does not only help you sleep, it also provides oxidative support that can aid your body in reducing oxidative stress, low-grade inflammation, and more!

ABOUT THE AUTHOR

Dr. Meredith Warner is the creator of Well Theory and The Healing Sole. She is a board-certified Orthopedic Surgeon and Air Force Veteran.

She is on a mission to disrupt traditional medicine practices and promote betterment physically, spiritually and mentally to many more people. She advocates for wellness and functional health over big pharma so more people can age vibrantly with more function and less pain.

At Well Theory, Our surgeon-designed products are FDA Registered and formulated to help people:

  • Manage the symptoms of musculoskeletal pain
  • Recover vibrantly from orthopedic related surgeries
  • Fill the gaps in our daily diets
  • Manage pain associated with inflammation

[VIDEO] The Perfect Turmeric Blend For Arthritis Relief

[VIDEO] The Perfect Turmeric Blend For Arthritis Relief

Arthritis forms when the protective coating over the ends of your bones, where they meet at joints, wears away due to injury, age, or genetic predisposition to certain forms of arthritis, like RA or psoriatic arthritis.

While there is no cure for arthritis, you do have effective and natural options for relief that don’t have the harmful side effects of heavy pharmaceuticals, or NSAIDs that can disrupt your gut biome.

Our Joint Health Multi contains turmeric-based curcuminoids, ginger, PEA, and piperine to provide a powerful option for baseline relief from arthritis pain and inflammation, while providing other health benefits as well.

blurb?

IT’S EASY TO GET STUCK IN OLD WAYS OF LIVING. IT’S TIME TO MAKE ROOM FOR THE NEW WAYS OF HEALING.

Natural Arthritis Relief With A Surgeon-Curated Formula

This multi contains 95% curcuminoids. One of these curcuminoids, Curcumin, is the active ingredient in turmeric responsible for its benefits in helping to relieve joint pain, stiffness, and inflammation.

When combined with turmeric, ginger, and piperine (to maximize absorption,) you get a daily dose of powerful, natural anti-inflammatories with no harmful side effects.

Tart Cherry Extract: Inflammation & Muscle Recovery

This daily supplement includes one simple ingredient: 1500mg of tart cherry extract. This concentrated superfruit promotes joint health, pain relief, and oxidative support within the body.

How Oxidative Stress Harms Nervous System Health

How Oxidative Stress Harms Nervous System Health

What Is Neurodegeneration?

Neurodegeneration is characterized by the progressive loss of selective neural subtypes in the CNS (central nervous system).

Accumulating evidence shows this is mediated by mitochondrial damage.

The common mechanism for lifestyle and non-communicable chronic diseases (NCDs) is mitochondrial dysfunction.

The Role Mitochondria Play In Nervous System Health

Mitochondria are responsible for energy production in cells; they produce the fuel used by all other cellular processes.

Think of mitochondria as a central processing unit; it takes external nutrient input and then produces energy output. Energy is in the form of ATP (adenosine triphosphate) and they also produce important lipid species and provide metabolic substrates for post-translational modifications for cell signaling by DNA.

Part of the process of the electron transport chain (ETC) which is how mitochondria make energy is a byproduct called ROS (reactive oxygen species). These unpaired electrons or free radicals can damage the mitochondria, mitochondrial DNA and other cellular processes. 

The mitochondria have a system to check the ROS from damaging cells, but it is often overwhelmed due to chronic inflammation and excessive oxidative stress.

The mitochondria create energy from nutrients in the inner mitochondrial membrane. Here in the oxidative phosphorylation chain superoxide is made. 

This is a common ROS in the cell formed at complexes I and III during the ECT. This is formed when an oxygen molecule gains an electron. The superoxide anion is then converted to hydrogen peroxide by superoxide dismutase (SOD); this is an important ROS producing enzyme. 

 

The H2O2 molecule can then become a massively damaging hydroxyl radical; this is highly reactive and causes oxidative damage to everything it touches.

ATP is made from ADP in the mitochondria by ATP synthase; this charges the battery of the cell. ATP is the main form of energy and is able to discharge the energy whenever needed by other cells and cell processes.

2ADT molecules can also be converted to an AMP and and ATP molecule by adenylate kinase; these levels of AMP are monitored by AMPK. If AMPK senses too much AMP, then the cell is under-energized. Likewise, too little AMP means the cell is making too much energy.

Low energy states prompt AMPK to initiate protective functions and longevity functions of the cell.

 

The Importance Of Supporting Healthy Mitochondria:

The brain and nervous system require a massive amount of energy to function, and this energy is provided by mitochondria.

Dysfunctional mitochondria basically can’t adapt to a changing environment. Normally, these organelles inside our cells are able to change according to demand. The demand changes according to the stress applied and environment.

Read More: Why You Should Protect Your Mitochondria – And How To Do It

Neurons are generally very long-lived cells; they do not turn over very fast. This means that neurons accumulate damage over time. 

Mitochondrial failure causes too little energy to be produced and not enough repair and detoxification ability for the brain. 

This ultimately results in neuroinflammation and neurodegeneration.

The mitochondria play a critical role in nerve and neuron function. Cells in the PNS (peripheral nervous system) and CNS rely on mitochondrial integrity. Aberrant mitochondrial quality control plays a large role in degeneration of the nervous system. 

Human cells have developed systems for mitochondrial quality control to protect cells from the overproduction or under-neutralization of reactive oxygen species.

Mitochondrial quality control includes:

  • Proteostasis
  • Biogenesis
  • Dynamics
  • Mitophagy
  • Autophagy

Mitochondrial Dysfunction And Inflammation:

A key cause of inflammatory pathways is failure of mitochondrial biogenesis, or biogenetic failure. In these situations there is an increase in calcium levels in the cytoplasm, there is oxidative stress (from ROS) and there is a decrease in normal mitochondrial DNA.  

Mitochondria undergo fusion and fission on a continual basis.  Fusion allows for more energy production.  Fission allows for the repair or removal of damaged mitochondrial DNA and organelles.  A failure of either will lead to an accumulation of inflammation and ROS within the brain which then damages neurons.   

Mitochondrial fission regulates the release of pro-inflammatory mediators.  It does so through nuclear factor kappa light chain enhancer of activated B cells (NF-kB) and MAPK (mitogen activated protein kinase) signaling.  Chronic activation of microglial (CNS support cells) can contribute to neuronal defection.  

One theory is that the accumulation of mitochondrial ROS activates the NLRP3 inflammasome-dependent pathway that elicits chronic inflammation. The NLRP3 inflammasome complex triggers the production of pro-inflammatory cytokines and induces mitochondrial fragmentation. This impairs energy production and disrupts the CNS cell balance.

While the NLRP3 inflammasome complex is crucial for defense against pathogens, it is also the source of many NCDs (AD, gout, autoinflammatory disease, DM, atherosclerosis). Precise control of the NLRP3 inflammasome pathway is mandatory for the health of the cell.

How To Improve Mitochondrial Health

There are ways to improve the function and quality of mitochondria. Two well-known and studies methods are calorie restriction and exercise. Both methods employ a negative balance in terms of nutrient input and energy output needs. By producing a negative balance, the mitochondria are challenged. A challenged mitochondria will improve its function and abilities. 

The challenged mitochondria is better at biogenesis, energy production and other tasks. The unchallenged mitochondria fragments and fails; this is the heart of the NCD problem.

There is a profound effect on mitochondria by exercise. Sustained strenuous physical exercise can double the mitochondrial contents and activity. It will also increase the coupling of mitochondria and improve efficiency and function. 

One of the ways that enhance function of mitochondria during calorie restriction or exercise is the AMPK (AMP-activated protein kinase) path. AMPK is an energy sensor. This molecule is deacetylated during fasting or exercise by SIRT-1. Deacetylation of AMPK increases its activity. 

AMPK functions to sense energy imbalances in the cell and then to initiate cell protection. When the energy supply is low, the cell and organism will respond by slowing down aging and increasing protection from many age-related problems.

Providing antioxidants also improves mitochondrial function by allowing for excessive levels of ROS to be removed from the organelles and cells. Additionally, anti-inflammatory molecules also improve function by protecting the cell membranes and changing the environment of chronic inflammation to a more healthy one.

Less inflammation means less reactive oxygen species and less oxidative stress.

There must be harmony in the generation of mitochondrial components from the nuclear and mitochondrial genomes. This is achieved by the PPAR-gamma, SIRT1 and AMPK signalling pathway. There must be a balance between mitochondrial fusion and fission.

Fusion is the interconnection and enlargement of mitochondria to produce more energy. Fission is the repair/replace cycle for damaged mitochondria. For example, an abnormal accumulation of autophagy vacuoles from fission is a prominent feature of neurons in AD.

Defective oxidative phosphorylation in the mitochondria leads to excessive amounts of ROS and therefore elevation of oxidative stress. This causes more mitochondrial damage and a negative feedback loop happens. The role of antioxidants and anti-inflammatories is to stop this loop and to remove the unneeded ROS.

Many of our products are designed to help reduce inflammation. In particular, our Nervous System Multi is designed to improve neural health by optimizing mitochondrial function.

ABOUT THE AUTHOR

Dr. Meredith Warner is the creator of Well Theory and The Healing Sole. She is a board-certified Orthopedic Surgeon and Air Force Veteran.

She is on a mission to disrupt traditional medicine practices and promote betterment physically, spiritually and mentally to many more people. She advocates for wellness and functional health over big pharma so more people can age vibrantly with more function and less pain.

At Well Theory, Our surgeon-designed products are FDA Registered and formulated to help people:

  • Manage the symptoms of musculoskeletal pain
  • Recover vibrantly from orthopedic related surgeries
  • Fill the gaps in our daily diets
  • Manage pain associated with inflammation

Surgeon Formulated
For Your Peace of Mind

Natural Ingredients + Cutting-Edge Medical Breakthroughs.

100% NATURAL PAIN RELIEF FOR PEOPLE WORLDWIDE

[VIDEO] Plant-Based Arthritis Relief With CBD Oil

[VIDEO] Plant-Based Arthritis Relief With CBD Oil

If you live with arthritis, you know that your pain can be worse on some days than others. This CBD Oil Tincture gives you natural, plant-based relief that you can adjust as needed throughout your day, and day-to-day as your pain relief needs change.

CBD naturally engages your body’s regulatory system to reduce its inflammation response – relieving inflammation throughout the body and in joints while soothing pain. 

Our Broad Spectrum tincture is designed to be tasteless and comes with a dropper for easily customizable relief!

IT’S EASY TO GET STUCK IN OLD WAYS OF LIVING. IT’S TIME TO MAKE ROOM FOR THE NEW WAYS OF HEALING.

Powerfully Anti-Inflammatory Herbal Ingredients

Dr. Meredith Warner’s new Joint Health Multi is designed to relieve sore joints while reducing inflammation over time with natural ingredients.

Highly absorbable & unique formulation with clinically studied ingredients to improve joint health, decrease joint discomfort, reduce pain, elevate brain health, and boost energy levels.

Full-Body Anti-Inflammatory & Antioxidant Support

This daily supplement includes one simple ingredient: 1500mg of tart cherry extract. This concentrated superfruit promotes joint health, pain relief, and oxidative support within the body.

Tart cherries have an abundance of anthocyanins and flavanols. These compounds allow tart cherries to reduce inflammation and decrease oxidative stress in the brain and throughout the body.

Early Signs Of Arthritis

Early Signs Of Arthritis - And How To Find Relief With CBD

If you have begun to notice stiffness, aching, and swelling in your joints, and have difficulty moving freely, especially in the morning, it may be time to talk to your doctor about arthritis. 

There are well over 100 different types of arthritis, so this first conversation can seem daunting at first. Keep reading to find out which symptoms you should watch out for and mention to your doctor, and what different types of treatment you can expect for your condition.

Early Intervention Is Key

to lessening your arthritis symptoms & preventing injury

It’s important to intervene early if you think you may have arthritis. Arthritic conditions are degenerative in nature, so the longer your symptoms go without being addressed, the worse your pain and condition may become. This increases your risk of joint damage and having to undergo invasive procedures, such as surgery.

You will want to first pay attention to the symptoms you’re experiencing. Do they usually occur in the mornings, evenings, or after exercise? If the pain began suddenly, try to remember if and how you may have injured the affected joint. It is possible that you may have sprained it and eventually, the injury will heal. 

If the pain persists for a couple weeks or more, it’s likely time to see a doctor. Some inflammatory arthritis conditions present suddenly as well.

If you have symptoms other than pain, such as redness, swelling, or heat, you’ll want to make sure to see a doctor soon. 

It’s important to pay attention to these seemingly small details, as it will help your doctor accurately diagnose your condition and get you started on a treatment plan.  Some arthritic conditions are accompanied by other problems such as rashes or intestinal issues. 

Things You Can Try At Home

but where do you start?

While we caution you against self-diagnosing and self-treating, there are some things you can do to alleviate pain while you’re waiting to see your doctor. 

Hot and cold compresses relieve pain and reduce swelling, respectively, and over-the counter pain relievers can reduce inflammation as well.  Many states allow direct access to trained and professional physical therapists as well; if they feel a physician visit is warranted they will request it for you.

Herbal remedies, such as CBD cream, oil, or CBD-infused multivitamins, are great options for arthritic pain as well. 

CBD does not cure or treat arthritis; rather, the plant-based CBD can assist with the symptoms from the inflammation and pain.  

 

However, these are not options you should use in lieu of doctor-led treatments. They can relieve pain and inflammation in the short term, however, you will want to develop a treatment plan for your long-term joint care and function.

Arthritis:

how it's diagnosed

While your general practitioner may be able to diagnose your pain as arthritic in nature or even identify the specific condition, seeing an orthopedic surgeon or a  rheumatologist is your best bet for receiving an accurate diagnosis and personalized treatment plan. 

First visit your primary care physician, who will then recommend a specialist if you need one.  Many primary care physicians are perfectly capable of taking care of basic arthritic symptoms too. 

Arthritis, especially if it’s time-related, is a condition that you will likely be managing for quite a while. It is very likely your doctor will recommend lifestyle changes, including changes to your diet, exercise routine, and more. They may put you on a supplement or prescription regimen depending on the severity of your condition. You may be referred for surgery or a physical therapy regimen as well.

Unfortunately, arthritis is typically incurable, but you can slow your joint degeneration and reduce your pain with mindful lifestyle changes.

Try gentle exercise, an anti-inflammatory diet, and adding natural anti-inflammatories to your supplement regimen.

 

ABOUT THE AUTHOR

Dr. Meredith Warner is the creator of Well Theory and The Healing Sole. She is a board-certified Orthopedic Surgeon and Air Force Veteran.

She is on a mission to disrupt traditional medicine practices and promote betterment physically, spiritually and mentally to many more people. She advocates for wellness and functional health over big pharma so more people can age vibrantly with more function and less pain.

At Well Theory, Our surgeon-designed products are FDA Registered and formulated to help people:

  • Manage the symptoms of musculoskeletal pain
  • Recover vibrantly from orthopedic related surgeries
  • Fill the gaps in our daily diets
  • Manage pain associated with inflammation
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