The Complete Beginner’s Guide To PEA

The Complete Beginner's Guide To PEA

Hi, Dr. Meredith Warner here -

I discovered palmitoylethanolamide (PEA) during my quest to improve my knowledge and applications of natural remedies for my patients, my family, and myself. PEA is one molecule in a family of natural and endogenous fatty acids (meaning that they exist within the human body) that act on a variety of receptors. PEA is of the same family that anandamides are, or the neurotransmitters that are affected by CBD.

PEA, along with oleoylethanolamide (OEA) and other N-acylethanolamines (NAEs), are biologically active lipids. PEA is a strong and natural anti-inflammatory and is essentially devoid of unwanted effects in humans. It is also useful for treating eczema, controlling pain, and preventing neurodegeneration among other benefits.

PEA is naturally present within human beings and is produced on demand in the lipid bilayer of cells. It has a short half-life and is metabolized when not needed. When taken orally, it has a high volume of distribution throughout the body and is especially effective in the brain and for nervous tissues.

PEA is found in high levels during several inflammatory and painful disorders due to its innate anti-inflammatory activities. It basically functions as an internal regulator of pain.

How PEA Works

a natural option for pain + inflammation relief

PEA in all available clinical trials produces significant pain relief without any side effects. This is true for pain intensity in patients with chronic pain and/or neuropathic pain, too.

PEA acts mostly on non-neuronal cells of the nervous system. Current thinking in chronic and neuropathic pain targets these cells as they are most responsible for the actual sensation of pain. This is sometimes called gliopathic pain or asteropathic pain.

It has been discovered that mast cells are particularly active around peripheral nerve endings in the pain situations. PEA downregulates the inflammatory and stimulatory activities of the mast cells. Peripheral mast cells are pro-nociceptive (pain-perceiving). PEA is anti-nociceptive (blocks pain perception). PEA targets receptors and cellular activities that are not traditional to common pain medications.

PEA is a cannabimimetic compound, meaning PEA works with cannabinoid receptors within the body. It is also known as an indirect endocannabinoid.

PEA should be a daily supplement to enhance the activities of the family of lipids to which it belongs. PEA is natural and is normally produced by the human body. Most of us are likely deficient. PEA is an indirect endocannabinoid and as such plays an important role in the endogenous regulatory system of the endocannabinoids.

How To USE PEA

PEA is naturally analgesic (anti-pain), anti-inflammatory, and will downregulate mast cells’ activities and thus protect peripheral nerve endings. PEA is great for the brain and acts on the support cells such as the glial cells and astrocytes.

If you do not have enough PEA, you will lack the full regulatory ability of the endocannabinoid system. This means that all other systems in your body will lack balance.

PEA is a natural way to produce many of the same effects as CBD.

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PEA helps control pain in these conditions:

  • Injury
  • Intestinal inflammation
  • Chronic migraine
  • Neuropathic pain
  • Cerebral ischemia
  • Multiple Sclerosis (MS)
  • Sciatica
  • Post-laminectomy syndrome
  • Fibromyalgia
  • Rheumatoid arthritis
  • Diabetic neuropathy
  • Post-operative pain
  • TMJ pain from arthritis
  • Arthritis pain
  • Lower Back Pain (LBP)
  • Nerve-mediated pain like carpal tunnel and tarsal tunnel
  • Primary dysmenorrhea
  • Chronic pelvic pain such as endometriosis

Purposefully-Paired All-Natural Ingredients

Realizing the potential of PEA in natural anti-inflammatory recovery, Dr. Warner has developed Well Theory products exclusively for our sister company, The Healing Sole. The essential PEA multivitamin and pain-relieving foot cream from Well Theory has been purposefully-crafted by Dr. Meredith Warner to relieve pain naturally, effectively, and quickly. The ingredients combined within these products work together to regulate homeostasis, reduce inflammation, and support stronger, healthier muscles.

Find Natural Relief

with the full line of Dr. Warner's Well Theory products

For these reasons, PEA is the essential ingredient in Dr. Warner’s pain-fighting cream and multivitamin – available exclusively on The Healing Sole. Well Theory as a whole is designed to help you live life better – with less pain, better health, and a vibrancy that radiates from within.

These products, like our CBD Well Theory product line, improve your physical and mental health from the inside out so that you can live energetically and age vibrantly.

Her PEA cream and multivitamin helps to relieve pain when you need it most, lower inflammation, and support a healthy endocannabinoid system.

Try these products for yourself today! 

Visit The Healing Sole 

ABOUT THE AUTHOR

Dr. Meredith Warner is the creator of Well Theory and The Healing Sole. She is a board-certified Orthopedic Surgeon and Air Force Veteran.

She is on a mission to disrupt traditional medicine practices and promote betterment physically, spiritually and mentally to many more people. She advocates for wellness and functional health over big pharma so more people can age vibrantly with more function and less pain.

At Well Theory, Our surgeon-designed products are FDA Registered and formulated to help people:

  • Manage the symptoms of musculoskeletal pain
  • Recover vibrantly from orthopedic related surgeries
  • Fill the gaps in our daily diets
  • Manage pain associated with inflammation

Surgeon Formulated
For Your Peace of Mind

Natural Ingredients + Cutting-Edge Medical Breakthroughs.

100% NATURAL PAIN RELIEF FOR PEOPLE WORLDWIDE

Meet Dr. Warner’s New PRP Collagen Complex Cream

Meet Dr. Warner's New PRP Collagen Complex Cream

Platelet-Rich Plasma: A New Anti-Aging Treatment

designed with curated botanicals + medical expertise

Hi, Dr. Meredith Warner here –

I have over 20 years experience with platelet rich plasma PRP and other regenerative treatments for connective tissue and collagen. I have used PRP in countless surgeries and for many orthopedic, wound healing and connective tissue problems encountered in my practice.

Likewise, I have incorporated natural and alternative types of treatments into my practice and personal health for the same amount of time. I have a deep knowledge base of the properties and rejuvenating/healing abilities of phytochemicals like terpenes, flavonoids, sesquiterpenoids, alkaloids, etc.

I have combined my knowledge of connective tissue and the healing of collagen and skin with my knowledge of the healing abilities of phytochemicals and PRP (platelet-rich plasma) in a new and exciting product.

PRP And Facial Rejuvenation:

surgeon-tested & surgeon-approved

I personally wanted to find a way to use PRP for facial rejuvenation. I did not have the time or desire to undergo a microneedling procedure – during which a practitioner would poke many small holes in my face to administer PRP injections. Currently, one of the standards in facial rejuvenation is to combine microneedling with PRP.

Microneedling is thought to stimulate collagen healing by penetrating the skin with small needles and causing damage to the subdermal layer. This damage is then healed by the natural healing mechanisms of the human body. At the time that the holes are made in the skin, PRP can be spread over the face in the hopes that it will enter the subdermal region through these holes.

Read More: Beginner’s Guide To PRP

I have long thought that this method of treatment seems primitive and there must be a better way to gain more youthful skin. Also, we know that inflammation is the source of mitochondrial damage and can be an underlying reason for the development of wrinkles and certain types of diseases such as cancer.

It has never made a lot of sense to me to induce inflammation to cure the results of inflammation. I thought about this for a long time and developed my PRP Collagen Complex.

The Science Behind Dr. Warner's PRP Collagen Complex

Essentially, I knew that there are certain phytochemicals that can drive PRP through the outer skin layer and to the underlying collagen in the subdermal plane – and mixing them with PRP would deliver an effective anti-aging treatment without invasive microneedling.

The subdermal plane beneath the outer layer of skin is the area that requires healing and growth to improve the fullness and freshness of the face. To that end, I have developed a method to safely put PRP in that region and to allow for rejuvenation of the skin, and have tested it on myself for months to ensure its safety and effectiveness.

Phytochemicals like CBD are terpenes that interact with the body on a molecular level. The research behind Well Theory – developing more natural, less invasive methods of treatment – is what informed the design of this PRP Collagen Complex, currently available in my clinic here in Baton Rouge.

Visit Warner Orthopedics

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How The PRP Collagen Complex Works: Naturally

“My goal is to help people age better, age fitter, and enjoy their old age. We’re all going to get old. You can’t stop that

Meredith Warner, MD

This product harnesses time-tested and safe medical grade phytochemicals and topical components for the purpose of allowing individuals to place PRP where it is needed most on a daily basis.

The platelets in PRP have been proven in many studies to provide an abundant amount of growth factors. The phytochemicals in my complex not only drive the PRP through the skin but also clean the skin naturally. My proprietary blend of certain terpenes allows for anti-bacterial and anti-viral actions at the cellular level of the skin.

At Well Theory, we are obsessed with innovations that improve your overall health and well-being – naturally, and holistically. Consider this blog, the Herbal Kitchen, and our products your personal resource to a life lived well.

 

ABOUT THE AUTHOR

Dr. Meredith Warner is the creator of Well Theory and The Healing Sole. She is a board-certified Orthopedic Surgeon and Air Force Veteran.

She is on a mission to disrupt traditional medicine practices and promote betterment physically, spiritually and mentally to many more people. She advocates for wellness and functional health over big pharma so more people can age vibrantly with more function and less pain.

At Well Theory, Our surgeon-designed products are FDA Registered and formulated to help people:

  • Manage the symptoms of musculoskeletal pain
  • Recover vibrantly from orthopedic related surgeries
  • Fill the gaps in our daily diets
  • Manage pain associated with inflammation

Surgeon Formulated
For Your Peace of Mind

Natural Ingredients + Cutting-Edge Medical Breakthroughs.

100% NATURAL PAIN RELIEF FOR PEOPLE WORLDWIDE

Beginner’s Guide to PRP

Beginner's Guide To PRP

Platelet-Rich Plasma Therapy

what is is + why you need it

PRP, or platelet-rich-plasma therapy is a regenerative therapy that has been used in a variety of settings – aesthetic, surgical, wound care, and more.

Dr. Meredith Warner, founder of Well Theory, has over 20 years experience with platelet-rich-plasma (PRP) and other regenerative treatments for connective tissue and collagen health. She has used PRP in countless surgeries and for many orthopedic, wound healing and connective tissue problems encountered in her practice.

Dr. Warner’s clinical experience using this regenerative therapy inspired her to continue incorporating natural and alternative types of treatments into both her personal life and clinical practice. This has led to a deep understanding of such treatments and discerning whether or not her patients can benefit from them instead of more invasive procedures. She has been able to apply the powers of PRP into not just surgical procedures but for many outpatient injuries, degenerative conditions and for issues related to skin and connective tissue health.

How It Works

and why it works

PRP Therapy uses one of the body’s most efficient healing devices to improve and speed up recovery. Basically, PRP allows for the application of concentrated amounts of your own platelets to the damaged region. Platelets are filled with granules that hold growth factors and proteins integral to healing. Platelet activation is a crucial aspect of wound and soft tissue healing. 

Platelets are tiny cell fragments that help to promote healing in injured areas of the body and relieve pain. Without platelets there would be no ability for natural healing of the body from injury, disease, degeneration and environmental toxins or chronic inflammation.

PRP therapy works by harnessing one of the most essential parts of your body’s natural healing process and applying it in a concentrated form to where you need it most. This results in a faster, more effective rate of healing without further invasive procedures. This is a proven clinical therapy with significant benefits for patients.

Studies show PRP makes chronic conditions resemble a new injury and the healing response renews. This new response combined with the growth and healing factors that PRP provides can lead to an improved chance of healing, which may mean surgery isn’t necessary in some cases. If your provider indicates a need for surgery, ask if PRP is a viable option.

The Process Of PRP Therapy

what you can expect

If you are interested in PRP, here’s a general idea of what to expect.

Your blood is extracted using a sterile method, and then separated in a centrifuge in the office. This separates your plasma from the rest of your blood cells. After this, your PRP will be drawn into a syringe and applied where it’s needed most. In an aesthetic setting, your PRP may be added into a microneedling procedure and deposited under the skin in a series of small punctures. For problems such as tendinitis or degenerative muscles or connective tissues, often an ultrasound is utilized to target the injection of PRP to structures deep to the skin.

Dr. Warner recently developed a PRP Collagen Complex cream that bypasses microneedling altogether by harnessing the power of phytochemicals. Phytochemicals are generally from plant extracts and can interact with the human body in a variety of healing ways – CBD is an example of a phytochemical; it acts on the endocannabinoid system to reduce inflammation, anxiety, restore hormonal balance, and more.

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The phytochemical and phytonutrient blend Dr. Warner uses in this Collagen Complex helps to drive PRP through the tight skin barrier to the collagen and other connective tissues underneath, negating the need for microneedling or other tissue trauma and providing a powerfully revitalizing solution for those who want to use a powerful anti-aging treatment at home.

In a surgical setting, PRP is extracted and separated while you are under anesthesia typically, then injected where needed during your procedure. There are also outpatient PRP therapies available for those who need regenerative therapy to improve joint function, heal scar tissue, and more. During such procedures, your PRP is extracted, separated, and injected into the site of treatment (which is typically numbed beforehand.)

Regenerative Therapies

the future of medicine

“My goal is to help people age better, age fitter, and enjoy their old age. We’re all going to get old. You can’t stop that

Meredith Warner, MD

At Well Theory, our goal is to help you live and age better – with better function, increased vitality, and with less pain. Our healthy living research is centered on natural options for treatment that utilize lifestyle changes, natural botanical compounds, proper nutrition, and more. Dr. Warner practices patient-led, individualized medicine in her clinic, and developed Well Theory to extend the same resources to you.

Read More: Why Dr. Warner Cares

ABOUT THE AUTHOR

Dr. Meredith Warner is the creator of Well Theory and The Healing Sole. She is a board-certified Orthopedic Surgeon and Air Force Veteran.

She is on a mission to disrupt traditional medicine practices and promote betterment physically, spiritually and mentally to many more people. She advocates for wellness and functional health over big pharma so more people can age vibrantly with more function and less pain.

At Well Theory, Our surgeon-designed products are FDA Registered and formulated to help people:

  • Manage the symptoms of musculoskeletal pain
  • Recover vibrantly from orthopedic related surgeries
  • Fill the gaps in our daily diets
  • Manage pain associated with inflammation

Surgeon Formulated
For Your Peace of Mind

Natural Ingredients + Cutting-Edge Medical Breakthroughs.

100% NATURAL PAIN RELIEF FOR PEOPLE WORLDWIDE

Why Does CBD Work so Well?

Why Does CBD Work so Well?

CBD and The Medical Field

CBD is the newest trend in the health and wellness community – and is even making waves in the medical community for its health benefits as well. From fighting insomnia to reducing stress, treating seizures, and reducing inflammation, CBD has become the most well-known natural remedy for a host of conditions.

Read more: Can CBD Cure Epilepsy?

Because of CBD’s proven medical applications, there are many clinical trials being conducted – or have recently been conducted – showing its successful applications for the treatment of problems associated with conditions including (but not limited to) anxiety, pain + inflammation in joints, Parkinson’s, and more with limited, if any, side effects. 

This means that CBD has the potential to be a safe and holistic alternative to heavy pharmaceutical treatments, which often have discouraging side effects.

How Does CBD Work?

You might be wondering how CBD can be successfully utilized to treat so many different conditions – and you aren’t alone. Most of the research being performed by the medical and scientific communities focuses on how CBD interacts with the body.

Their research has found that CBD mimics endocannabinoids, which are chemicals that your body produces naturally. CBD itself is a phytocannabinoid, as such, it is able to attach to receptors in your body to exert its therapeutic effects. The two receptors it is known to either regulate or attach to are CB1 and CB2 receptors.

CB1 receptors are found mostly in the brain and are related to things like coordination, pain, emotions, appetite, and more.

CB2 receptors are more commonly found in the immune system, and influence the body’s inflammatory response and signal pain receptors. When you stub your toe and the tissue surrounding it gets swollen and inflamed, that is inflammation. CB2 receptors are found on cells involved in inflammation and therefore phytocannabinoids can directly influence that inflammatory response.

CBD has been shown to interact with the receptors on certain white blood cells – which makes it possible, therefore, for CBD to naturally suppress the body’s inflammatory response and balance pain. CBD is also able to modulate certain nervous system neurotransmitters and thus regulate mood. 

These neurotransmitters are essential to your overall health and well-being, and when these neurotransmitters are “misfiring,” aka, promoting neural imbalance and inflammation, it can wreak havoc on the body. Overly elevated or diminished production of certain endocannabinoids create imbalance in other physiologic systems; this causes imbalances and symptoms such as pain,depression, lower immune function, and more.

How CBD Promotes Balance

mentally & physically

When ingested or used in topical formulations, Cannabidiol has the ability to naturally increase your body’s endocannabinoid levels, but in addition to that, it protects your receptors from being overly stimulated. It has been shown to bind to CB1 receptors in a different pattern than the cannabinoids your body produces on its own, reducing the receptor’s ability to allow other cannabinoids to bind to it, thereby reducing its responsiveness. 

This is a good thing, as most imbalances are caused by overactive receptors – causing things such as anxiety, appetite, and fluctuating weight. CB1 receptors are balanced themselves, by CB2 receptors.


CBD does more than just bind to or alter the function of CB1 and CB2 receptors, however. It has the ability to interact with other receptors, such as serotonin receptors in the brain, and pain receptors that respond to temperature and respond with a pain and heat sensation.

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CBD can mimic serotonin and bind affect receptors in the brain, activating them and playing a role in reducing anxiety, depression, and more. It can also bind to the receptors that sense injury, reducing your body’s inflammatory response and promoting a more gentle, and appropriate, reaction to injury. 

When you are injured, discomfort occurs from the injury itself, and the swelling, heat, and pain that the body produces following the injury. CBD’s ability to bind to these receptors, called TRVP1 receptors, is what makes it a prime candidate for treating epilepsy and reducing discomfort caused by arthritic joints.

How Does It Interact With Medications?

If you are considering using CBD to manage symptoms related to inflammation, emotional distress, and more, you may already be taking medications prescribed by your doctor. Even if you are not on other medications, it’s wise to consult with your physician before starting a CBD regimen. Your physician will likely be able to recommend trustworthy brands and products that are suited for your particular condition.

Because of its wide range of uses, cannabidiol is becoming increasingly utilized for its therapeutic properties. Much of the science surrounding how it exerts its effects is still being developed, but early findings all point to it being a remarkably risk-free alternative to more side effect-prone medications. 

While it should never be used instead of prescribed medication (unless your physician gives you the go-ahead,) it has been shown in dozens of early trials to effectively reduce inflammation, curb anxiety, and improve overall well-being.

Ready to try CBD for yourself? Look no further than Well Theory – a surgeon-curated line of holistic CBD products designed to improve your overall health with emphasis on reducing inflammation in the musculoskeletal system, and restoring balance. 

 

ABOUT THE AUTHOR

Dr. Meredith Warner is the creator of Well Theory and The Healing Sole. She is a board-certified Orthopedic Surgeon and Air Force Veteran.

She is on a mission to disrupt traditional medicine practices and promote betterment physically, spiritually and mentally to many more people. She advocates for wellness and functional health over big pharma so more people can age vibrantly with more function and less pain.

At Well Theory, Our surgeon-designed products are FDA Registered and formulated to help people:

  • Manage the symptoms of musculoskeletal pain
  • Recover vibrantly from orthopedic related surgeries
  • Fill the gaps in our daily diets
  • Manage pain associated with inflammation

Surgeon Formulated
For Your Peace of Mind

Natural Ingredients + Cutting-Edge Medical Breakthroughs.

100% NATURAL PAIN RELIEF FOR PEOPLE WORLDWIDE

Can CBD Cure Epilepsy?

Can CBD Cure Epilepsy?

The Case of Billy Caldwell

The science surrounding CBD is nascent, yet promising. So far, the compound seems to be improving problems ranging from chronic pain to Crohn’s Disease.

But one particular area of CBD interest is in epilepsy treatment. For example, in a landmark 2018 study conducted by New York University’s Comprehensive Epilepsy Center, 225 patients suffering from Lennox-Gastaut syndrome given CBD found significant reductions in seizure occurrence versus a control group.

But there are some who claim to already have known that CBD is a miracle cure for seizures–some of whom have compelling stories.

One such person is a little boy named Billy Caldwell, whose life was saved when the government granted him a CBD prescription, which, tragically, it later took away.

Billy Caldlwell

first person to get a CBD prescription

Billy was in bad shape. In fact, the 14-year-old was dying from a severe form of epilepsy that was causing up to 100 seizures per day. To make matters worse, his condition was intractable, meaning that he could not get help through diet or medication.

But then, something miraculous happened. Not being able to rely on traditional cures to save her son, Billy’s mom put him on CBD to soothe his near-constant seizing.

At one point, Billy’s mom reported that her son had not had a single seizure in the over 300 days since starting the CBD supplement.

Not only did this give Billy a new lease on life, but it would eventually put his case in the media spotlight after becoming the first person to get a CBD prescription in Northern Ireland.

What happened

when his prescription wasn't renewed

Shortly after the seizure-free 300 day mark, the government did not allow the renewal of Billy’s CBD prescription.

His seizures promptly returned, reports the BBC.

His mother was outraged at what she perceived as an act of ignorance and callousness by the government. She called their reluctance to renew the prescription ‘orchestrated cruelty’ and is now fighting a legal battle for her son’s life.

There’s lots of hope for Billy Caldwell. CBD--though not easily accessible where he lives--is at least available. And the stigma surrounding the cannabis-plant derivative is slowly lifting.

Studies like the one performed at New York University are paving the way for both new uses for CBD as well as its acceptance into the mainstream. Likely, new science will emerge in the short term that will present even better news for seizure sufferers.

Learn more about the controversy surrounding CBD by reading this helpful blog!

ABOUT THE AUTHOR

Dr. Meredith Warner is the creator of Well Theory and The Healing Sole. She is a board-certified Orthopedic Surgeon and Air Force Veteran.

She is on a mission to disrupt traditional medicine practices and promote betterment physically, spiritually and mentally to many more people. She advocates for wellness and functional health over big pharma so more people can age vibrantly with more function and less pain.

At Well Theory, Our surgeon-designed products are FDA Registered and formulated to help people:

  • Manage the symptoms of musculoskeletal pain
  • Recover vibrantly from orthopedic related surgeries
  • Fill the gaps in our daily diets
  • Manage pain associated with inflammation

Surgeon Formulated
For Your Peace of Mind

Natural Ingredients + Cutting-Edge Medical Breakthroughs.

100% NATURAL PAIN RELIEF FOR PEOPLE WORLDWIDE

The Science Behind How You Heal

The Science Behind How You Heal

How you heal

an orthopedic surgeon's perspective

Hi, Dr. Meredith Warner here –

As an orthopedic surgeon, I not only specialize in surgical procedures – but also have to be an expert in the process of healing. Surgery is simply a means to the end – and the goal of each procedure is healing and the promotion of better form and function. I’d like to share a little bit of what I know about the physical process of healing with you today:

There are four main phases of healing that are universal and generally follow the same pattern and timing no matter what. If there is variation, that is when there are problems. Diabetics, for example, have differences in timing between the four phases of healing, which makes their wounds heal slower or become chronic.

Connective tissue is the stuff that puts a human together and makes the body “stick” together – not just tendons and ligaments. Connective tissue can be bone, ligament, nerves, muscles, tendons and the matrix (surrounding gel/fluid) that holds the cells in place. Its universality throughout the structures of the body serves as a reminder for the interconnectedness of the healing cycle.

When a connective tissue is injured, the collagen must be reformed and the structure of the material (skin, tendon, ligament, etc.) must be re-formed. The human body uses a four-step process that reliably achieves these goals if the environment is right.

The four phases of healing are hemostasis, inflammation, proliferation and remodeling.

Stage One:

Hemostasis

Just after an injury, the body is in a default mode to protect and survive. If, for example, an injury results in bleeding, the body stops the bleeding in an effort to preserve the tissue and save energy for possible fight or flight. The body does this primarily through the process of clotting.

A clot is a clump of platelets and inflammatory cells that are the first to arrive at the site of injury. They are called to the area by a complicated system of signals released into the bloodstream as soon as an injury occurs. At the scene of the wound, be it a cut, laceration, contusion, burn, chemical exposure, tear or anything, the platelets bind the exposed collagen of that tissue within the extracellular matrix. Once bound, the platelets begin to work.

Platelets are magical fragments of cells in the blood stream with awesome healing capacity. These begin to immediately secrete sphingosine-1-phosphate, thrombospondin, fibronectin, von Willebrand factor.

These then stimulate even more platelet action, promoting a release of clotting factors, which stop the bleeding – by causing a matrix of fibrin to develop that acts as a plug. This stable clot/plug then acts as a bed for substances and cells flowing into the wound, because the platelets in a clot also secrete growth factors that are integral to the next steps in healing.

Once these are released by platelets into the wound environment, other cells like neutrophils and macrophages enter the zone. PDGF recruits cells that form fibrin (fibroblasts) and then collagen begins to be deposited – beginning the tissue repair process.

Also read: Why You Should Consider a Multivitamin Before Surgery.

Stage Two:

Inflammation

The hemostasis phase starts immediately after an injury and overlaps with the inflammatory phase of healing. The inflammatory phase should only last a few days. If it persists, then chronic inflammation results and then chronic non-healing or poorly healing tissue is the outcome. For now, we will focus on a normal inflammatory phase of healing.

At the core of the healing process – and any process that occurs in the body – is something called the Endocannabinoid System, or ECS. The ECS governs each “task” your body undergoes – from triggering healing, the sensation of hunger, the sensation of pain, and especially the onset of inflammation.

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An overeager inflammatory response is often the root cause of many conditions. While it has its place in the context of healing, sometimes the ECS can be overloaded and promotes inflammation for longer than it is necessary, causing problems. Here is how inflammation is supposed to work, when the ECS is promoting a proper inflammatory response:


There is a group of signalling molecules in the bloodstream known as the ‘complement’ system. The complement system is activated at the time of the inflammatory phase. The system brings mediators that control the ‘leakiness’ of the surrounding blood vessels and also brings chemotactic factors. These in turn attract white blood cells (leukocytes) withing 24-48 hours after the injury.

The ECS System

and how it impacts inflammation

There is a group of signalling molecules in the bloodstream known as the ‘complement’ system. The complement system is activated at the time of the inflammatory phase. The system brings mediators that control the ‘leakiness’ of the surrounding blood vessels and also brings chemotactic factors. These in turn attract white blood cells (leukocytes) withing 24-48 hours after the injury.

Mast cells ( a type of leukocyte) appear as well and release granules filled with histamine. This is what causes what we think of clinically as inflammation. Mast cells and histamines are directly responsible for the redness, warmth, heat and pain of inflammation. Basically, the “leakiness” of the blood vessels in the region is increased by histamines and that allows for more healing and building cells to reach the zone of injury.

One of these cells is the neutrophil. Neutrophils remove bad things from the wound; they act to remove pathogens, damaged matrix, dead cells and ferign material. Neutrophils do this by phagocytosis; this is literally the ‘eating’ of the bad stuff. These are early and aggressive cells that begin the process of healing.

Next, monocytes and lymphocytes enter. These become macrophages. Macrophages are the workhorses of the demolition process, because they remove remaining dead and damaged tissues. The macrophages are more selective and powerful than the neutrophils and they do a more ordered and detailed “clean-up” of the damaged tissues.

Macrophages are also important because these cells also produce more healing factors. All of these growth factors and cytokines from macrophages act to cause the fibroblasts (fiber forming cells) to grow along with smooth muscle and endothelial cells. Endothelial cells are lining cells for vessels and skin.

Once the macrophages have finished cleaning up the injury site and started the healing and rebuilding process by providing the building blocks, they actually then remove the neutrophils – the cells that clean up debris and are one of the first cells that reach the injury. As these cells are removed, the proliferation phase begins.

Stage Three:

Proliferation

The proliferation phase is the actual construction phase of the tissue. Here is where the connective tissue is made whole again.

The fibrin and fibrin matrix that was produced at the inflammatory phase is merely a scaffold for the actual tissue. It is ‘granulation’ tissue and must be converted to the actual tissue needed; this may be smooth skin, strong tendons and ligaments, muscle or bone. The fibrin is replaced by collagen. This process usually starts on day 2 or 3 after the injury or surgery.

Proliferation involves angiogenesis (forming of new blood vessels), tissue granulation, re-epithelialization (formation of skin) and wound contraction (making a wound small).

The formation of new blood vessels is important because without blood nothing can heal. Blood brings oxygen and nutrition. Blood also allows for the efficient removal of waste. Different growth factors are released that signal for this process to happen.

The growth factors that are released also stimulate fibroblasts, which start the process of skin production. Skin building cells called keratinocytes flow to the injury site through the bloodstream and enter from the edges of the wound. Fibroblasts come from bone marrow when they respond to the chemical signals released during the inflammatory phase. These produce a matrix that allows for tissue to build. The matrix is made of proteins like collagen, fibronectin and hyaluronan. The fibroblasts are stimulated to produce by the PDGF and EGF that the macrophages make.

Some fibroblasts will turn into ‘myofibroblasts’. These have a muscular component and will literally pull the edges of the wound together to make it smaller as it heals.

Stage Four:

Remodeling

Wound remodeling is the last phase of healing. It usually starts at week 2 or 3 and can last up to a year in some cases. In this phase the tissue matures and becomes its true self. 

Weaker collagen is replaced by stronger collagen. Disorganized tissue becomes organized. The organization process is regulated by the fibroblasts that secrete an enzyme that degrades the collagen matrix of the wound bed and allows for the realignment of that collagen into organized networks. That organization is modified by stress, load, pressure, gravity and other mechanical and chemical forces. 

The key to good wound repair is the remodeling and re-organization of the extracellular matrix of the damaged tissue – how well it was constructed during the earlier phases of healing. This is why it is so important to make sure that you allow your body plenty of rest during this time, only undergoing physical therapy if advised to do so by your physician. Good nutrition is also key to making sure your body advances through the four phases of healing properly.

 

Prevent Chronic Inflammation

for proper healing

If the injury or condition goes without proper treatment, or if you have some underlying condition that makes you more prone to inflammation, you can experience chronic inflammation – which does more harm than good. chronic inflammation results and then chronic non-healing or poorly healing tissue is the outcome.

This is why ensuring you have a foundation of good nutrition and overall wellness is essential for your recovery process – from surgery or any other procedure. I recommend starting a supplement regimen to all my patients before their treatments, especially those that require surgery. Nutrition provides the building blocks for all functions of the body – and is especially important for recovery after an injury or surgery.

I developed my multivitamin with all the essential nutrients we commonly miss out on in our diets – and included Full Spectrum CBD powder in my formulation. CBD has been making waves in the medical and scientific communities for its powerful anti-inflammatory properties, making it a game changer for achieving full-body wellness.

 
ABOUT THE AUTHOR

Dr. Meredith Warner is the creator of Well Theory and The Healing Sole. She is a board-certified Orthopedic Surgeon and Air Force Veteran.

She is on a mission to disrupt traditional medicine practices and promote betterment physically, spiritually and mentally to many more people. She advocates for wellness and functional health over big pharma so more people can age vibrantly with more function and less pain.

At Well Theory, Our surgeon-designed products are FDA Registered and formulated to help people:

  • Manage the symptoms of musculoskeletal pain
  • Recover vibrantly from orthopedic related surgeries
  • Fill the gaps in our daily diets
  • Manage pain associated with inflammation