Osteoarthritis Is Inflammatory

Osteoarthritis Is Inflammatory

Yes, osteoarthritis really is inflammatory.

Most medical doctors and other health care providers have been taught for years and years that osteoarthritis (OA) is from wear-and-tear or from trauma. This fits a narrative in our society that damage and problems are always the fault of others. This also fits a narrative in professional schools that does not include anything about nutrition, prevention or overall wellness.

However, the current state of research and the current body of knowledge in basic and clinical science speaks to the completely inflammatory nature of OA. Indeed, the commonly thought reasons for OA are simply offshoots of inflammation.

How Prevalent Is Osteoarthritis

OA is the most common reason for disability worldwide right now.  It is the leading cause of chronic pain in our country and globally. Genetic factors seem to the be one of the strong determinants of suffering from OA.

Studies of identical twins have illustrated this. If one twin works in manual labor and is very active, while the other twin has a desk job and is inactive, their lumbar MRIs look the same. This indicates that ‘wear-and-tear’ is not really the culprit. Likewise, if one twin had trauma (as in a car accident) and another did not, again the MRIs are the same (Spine 2006). This indicates that trauma generally is also not the reason for OA. So what is?

Often, we think OA is an inevitable part of aging. OA must be like wrinkles and grey hair then, correct? However, certain populations around the world have little to no pain and are active well into the 90s and beyond. They do not have nearly the same numbers of joint replacement surgery that we have here.

Many older adults have absolutely no problem with OA at all. The Blue Zone populations complain about arthritis far less than do we, and they live into the 100s on a regular basis. So, arthritis can’t be inevitable and only due to aging then.

Osteoarthritis Is A Cartilage Disease

OA is considered a non-communicable chronic disease; that is, you can’t ‘catch’ OA. OA is basically a disease of damaged cartilage.

Articular (joint) cartilage is made of a very specialized connective tissue. It is comprised of collagen, chondrocytes, an extracellular matrix, smaller proteins like aggrecan, proteoglycan, cartilage oligomatrix protein, glycoproteins, water and fibronectin. There are also biologically active enzymes and cytokines present. Some enzymes function to degrade cartilage, some function in matrix turnover, some will stimulate the chondrocytes to make more cartilage and others manage the inflammatory environment of the joint itself. OA is a disease of the entire joint; it affects the bone, synovium, ligaments, fascia and the cartilage.

Genes associated with tissue metabolism are active for cartilage. Changes in the genes will trigger changes that lead to disorders in the cellular functional pathways. For example, the initiation and progression of OA can cause changes in the nf-kB pathway. This pathway is one of the primary drivers of chronic and low-grade inflammation. Different abnormalities that occur in regulatory proteins and genes lead to cartilage calcification and degradation.

Cartilage disease, like OA, is accompanied by synovitis. Synovitis is the inflammation of the lining of the joint capsule. Each joint has a capsule around it that contains the joint and the joint fluids. The synovial lining releases cytokines and matrix-degenerating enzymes into the joint and this leads to cartilage damage and the synovial cells continue to proliferate and produce even more damaging proteins. This, of course, results in progressive degeneration of the joint and joint tissues. The environment of increased levels of matrix metalloproteinases is responsible for the high level of proinflammatory cytokines that go on to damage the joint.

Today, many drug companies are looking for MMP-blocking agents to stop the cycle of inflammation. Another direction that drug companies are heading is toward blocking the smaller cytokines (IL-1, IL-6) that induce the MMPs to damage the cartilage.

Inflammation Is The Cause

Adipose tissue hormones and synovial products cause intense inflammation and are key to the development of OA. There is a correlation between the presence of inflammatory mediators and the development and progression of OA. It is well-known now that inflammation in the joint tissues is key for the start and progression of arthritis; the levels of inflammation also directly correlate to the levels of pain and dysfunction.  

There are inflammatory markers that can be checked in serum to assess the activity level of the disease process. The overall balance of good and bad cartilage is disturbed in the pro-inflammatory environment of arthritis. There are higher levels of IL-1beta, IL-6, TNF-alpha that have been released by the damaged cartilage cells. These in turn induce more damage to cartilage cells. Worse, the inflammatory environment stops the chondrocytes from producing new matrix and cells as they should.

Joint trauma is often considered the cause of osteoarthritis and joint degeneration. After trauma, generally a surgeon will stabilize the joint. However, studies have shown that the re-stabilization of the joint does not reduce the risk of degeneration. This means that the problem is not the trauma, or even the change in shape or character of the joint.

Human studies have found that inflammatory mediators are very high just after an injury, but they also remain high later as compared to control groups. It has also been discovered that there is a protective role for the hemarthrosis (blood-joint) that forms after injury; this substance produces IL-10 and IL-4, both of which are protective of the joint and are there to counteract the effects of the increased levels of inflammatory proteins. More IL-10 is also found in joint fluids after exercise; it is known that exercise is also protective of joint tissues.

It is thought that in some people, the pro-inflammatory response that occurs just after injury is not controlled late. This is why some go on to form OA but not all do so. The ability to control and manage the inflammatory state of the joint has nothing to do with the trauma of course.

Other Factors That Influence Osteoarthritis

The strongest systemic influence on OA appears to be obesity. Obesity affects both weight-bearing and non-weight-bearing joints, therefore the problem can’t simply be load. Likewise, people of the same height but with more muscle than fat tend to have less arthritis than the counterparts.

The problem with obesity is that adipose tissue produces and promotes inflammation. Inflammatory substances found in the serum of the obese include certain free fatty acids, cytokines, adipokines and reactive oxygen species are very prevalent with obesity. For example, leptin and adiponectin have catabolic and inflammatory influence on cartilage. Likewise, weight loss is known to reduce circulating levels of IL-6 and TNF-alpha. This is true with or without any sort of joint trauma.

Weight loss protects cartilage. The beneficial effects of exercise seen on joints in overfed mice was found to be due to a reduction in inflammatory mediators, not the actual loss of poundage.

Inflammation happens without trauma most of the time. Beside the inflammation caused by the systemic condition of obesity, there are other mechanisms of inflammation and OA.

The body will produce what are known as ‘danger signals’ in the setting of damaged tissues, abnormal proteins or DNA, or infection. For example, the receptor for advanced glycation end products (RAGE) will pick up on the danger signals made by the advanced glycation end products (AGEs). AGEs are damaging proteins caused by oxidative stress, inflammation and hyperglycemia. Likewise, they are consumed in most Americans’ diets on a daily basis. The AGEs actively damage collagen and induce the inflammation associated with OA.

This happens just by living and is not due to any sort of wear-and-tear or traumatic incident. Rather, the danger signals are simply from the levels of chronic inflammation and reactive oxygen species that are prevalent in most modern humans right now.

Adopting An Anti-Inflammatory Diet

Simply eating a more anti-inflammatory diet can have a large effect on the pain and symptoms of arthritis.  A diet does nothing to change and so-called wear-and-tear, nor will a diet reverse any trauma or injury that may have occurred.

This leads one to wonder, how can what I eat modify the pain my joint feels? The answer is that the diet reduces the overall burden of the inflammatory proteins and the reactive oxygen species that are responsible for the pain of arthritis.

Foods found in the Mediterranean diet are high in omega-3 fatty acids, beta carotene, magnesium, fiber and olive oil (omega-9 fatty acids); all of these actively reduce the levels of inflammatory proteins in the body.  

Just two weeks after switching to a plant-based diet, a group of people with painful arthritis had less pain (Arthritis. 2015).  A research group followed 4000 patients for a different study and found that the ones that followed the Mediterranean diet were less likely to develop joint problems (Am S Nut. 2016). This means that arthritis must be caused by far more than simple wear-and-tear of life; it is clear that inflammation is the cause and most likely will be the cure.

ABOUT THE AUTHOR

Dr. Meredith Warner is the creator of Well Theory and The Healing Sole. She is a board-certified Orthopedic Surgeon and Air Force Veteran.

She is on a mission to disrupt traditional medicine practices and promote betterment physically, spiritually and mentally to many more people. She advocates for wellness and functional health over big pharma so more people can age vibrantly with more function and less pain.

At Well Theory, Our surgeon-designed products are FDA Registered and formulated to help people:

  • Manage the symptoms of musculoskeletal pain
  • Recover vibrantly from orthopedic related surgeries
  • Fill the gaps in our daily diets
  • Manage pain associated with inflammation

Common Interactions with Well Theory Supplements

Common Interactions With Well Theory Supplements

About ¼ of Americans that take prescription pharmaceuticals also take supplements. Somewhere between 40% and 60% of those with chronic diseases do as well. Side-effects of natural products are exceedingly rare, however many people wonder if the natural product will interfere with the prescription medication.

How Our BODIES Process MEDICATIONS AND HERBAL SUPPLEMENTS

Prescriptions are generally processed in the liver in humans. Certain enzymes within the liver are responsible for breaking apart the drug and then allowing the biologic effects to take place.  

Interactions between an herb or extract and a drug usually occur as a pharmacokinetic interaction; this means the processing rates of each are changed. 

If the rate of processing in the liver changes, then the level of the drug and its effectiveness could also be changed. 

In order to change the pharmacokinetics of a given pharmaceutical, the herb must change the absorption, distribution, metabolism and excretion of the drug.

How Pharmacodynamics Are Changed

Occasionally, an herb or extract might directly interfere with the way a drug works. This is called a change in the pharmacodynamics.

Most of the drug-processing in the liver uses enzymes in the cytochrome P450 super family. In fact, about 80% of all manufactured drugs use these enzymes. 

There are 6 that are considered common. These are the following:

  • CYP1A2
  • CYP2C9
  • CYP2C19
  • CYP2D6
  • CYP2E1
  • CYP3A4

Of these, CYP2D6 and CYP3A4 are responsible for almost 50% of all drugs. If you know what enzyme is primarily utilized by your medication, then you can assess the herbal interaction with that given enzyme – if they use the same enzyme.

Drug Interactions

with Anticoagulants

Of all medications, people most commonly ask about the interaction of herbs and extracts with anticoagulants.

Warfarin

Warfarin is still the most commonly prescribed anticoagulant globally. This is a Vitamin K antagonist. For those on Warfarin, a very tight range of serum levels are needed for effectiveness. The CYP2C9 enzyme is heavily involved in the metabolism of Warfarin. Most interactions with Warfarin involve other prescription drugs, or OTC drugs.

Some herbal remedies are known to act on the CYP2C9 system in the lab, but clinically there is no issue. No food or nutrient has been shown to strongly interact with Warfarin (unless it contains Vitamin K). Soybeans hold a lot of vitamin K. There is a potential interaction with grapefruit due to the furanocoumarins.

There is one reported case of an interaction with a woman on Warfarin who consumed large amounts of chamomile too; this was due to CYP1A2, 3A4 and maybe 2C9. There is a clinically significant reaction of mango and Warfarin due to the inhibition of CYP2C19 by retinol found in the mango.

St. John’s wort will reduce the effectiveness of Warfarin.

Thrombin And Factor Xa Inhibitors

Direct oral anticoagulants are another class of medications to thin the blood. These include thrombin and Factor Xa inhibitors. 

There is no direct evidence of food or herbal interaction here. However, it is wise to discuss herbs such as St. John’s wort with your physician of course. 

Most direct factor Xa inhibitors are processed by the CYP3A4 enzyme.  Some supplements increase levels of medication in the blood, while others will reduce the levels. The same is true for direct thrombin inhibitors.   

Herbs Known To React With Medications

Two herbs are known to have clinically relevant interactions with prescription and OTC medications; these are St John’s Wort and Goldenseal.

There is one study that showed an effect of curcumin on CYP1A2 (it induced enzyme activity). This could make it interact with antidepressants or antipsychotics. It may also interact with the 3A4 enzyme.

Most physicians become concerned when a patient is on chemotherapeutics; in this case, as always, you should check with the prescribing physician.

Both cinnamon and turmeric are thought to increase anticoagulation a bit as well. Many people on Warfarin avoid turmeric due to the increase in bleeding potential.

Of course, many people on anticoagulants still take aspirin or NSAIDs daily. These definitely cause problems with prescription anticoagulants; these problems are more clinically relevant than any due to a plant or herb.

Herbal Supplements Compared To

eating or drinking herbs

The risks inherent to supplements are the same risks inherent to eating or drinking the same plants.

For example, there is a case report of a man on dabigatran who was hospitalized for bleeding after consuming a mixture of boiled cinnamon and ginger.  In fact, herbal teas are the most commonly consumed supplement by those on such anticoagulants.

If you are on a direct thrombin or Factor Xa inhibitor ask your physician about the following herbs and see what dose they might recommend: danshen, dong quai, ginseng, ginger, gingko biloba, green and chamomile tease, St. John’s wort, turmeric.  

Do Fruit And Berry Supplements

interact with prescriptions?

Brightly colored fruits and berries have abundant amounts of phytochemicals and antioxidant power.

For example, tart cherry extract holds anthocyanidins and these allow the extract to provide excellent pain relief and strong antioxidant benefits.

In general, the effect of plant phytochemicals such as anthocyanidins, proanthocyanidins and phenolic acids is much weaker on liver enzymes than the effect of grapefruit (furanocoumarins).  Berries and berry extracts are poor inhibitors of liver enzymes. They have little to no effect on most drugs.

Consult With Your Treating Physician

For surgery that requires anesthesia, one rule of thumb is to stop herbal remedies about 5 days prior to the procedure. This will ensure there are no interactions with the agents used for sleep and pain control during surgery.

If you have a concern, we always recommend that you consult the treating physician. However, most American-trained physicians will likely have no idea how to answer the question.

There are resources available to the public. These include the NIH Office of Dietary Supplements, the NIH National Center for Complementary and Integrative Health, and information on the Memorial Sloan Kettering Cancer Center’s website.

ABOUT THE AUTHOR

Dr. Meredith Warner is the creator of Well Theory and The Healing Sole. She is a board-certified Orthopedic Surgeon and Air Force Veteran.

She is on a mission to disrupt traditional medicine practices and promote betterment physically, spiritually and mentally to many more people. She advocates for wellness and functional health over big pharma so more people can age vibrantly with more function and less pain.

At Well Theory, Our surgeon-designed products are FDA Registered and formulated to help people:

  • Manage the symptoms of musculoskeletal pain
  • Recover vibrantly from orthopedic related surgeries
  • Fill the gaps in our daily diets
  • Manage pain associated with inflammation

[VIDEO] Natural Medicine Takes Time

[VIDEO] Natural Medicine Takes Time

As a physician in private practice, Dr. Meredith Warner’s goal is to help support her patients in improving their health and overall well-being. That’s why she founded Well Theory!

Our products are designed to help you achieve your health goals within the comfort of your own home and your daily routines. With the right support, you can establish your own wellness goals – and achieve them.

Give it time! Like all good things, holistic, natural medicines take time. At Well Theory, we don’t believe in quick fixes that can have harmful side effects. We want to help you build a better you, from the inside out.

IT’S EASY TO GET STUCK IN OLD WAYS OF LIVING. IT’S TIME TO MAKE ROOM FOR THE NEW WAYS OF HEALING.

Tart Cherry Extract

A Powerhouse Supplement For Muscle Recovery & Inflammation Support

Orthopedic Surgeon Dr. Meredith Warner, LOVES TART CHERRY! She developed these tart cherry supplements for those looking for natural pain relief without NSAIDs and recovery for overused muscles and joints.

Joint Health Multi

Dr. Meredith Warner’s new Joint Health Multi is designed to relieve sore joints while reducing inflammation over time with natural ingredients.

Highly absorbable & unique formulation with clinically studied ingredients to improve joint health, decrease joint discomfort, reduce pain, elevate brain health, and boost energy levels.

4 Reasons to Take Gaba Daily

4 Reasons to Take Gaba Daily

Not many people are familiar with GABA. So what is it? GABA or Gamma-aminobutyric acid is a neurotransmitter that helps send messages between the brain and the nervous system.  This nonprotein amino acid is found in almost every prokaryotic (lacks organelles or internal membranes) and eukaryotic (having a nucleus and internal membranes) organism.  It is a large part of the pool of free amino acids actually.  

Gaba is a bioactive compound that may be found in foods. In plants, it acts in the Krebs cycle and helps with energy production. For humans, it is a powerful neural signal transmitter. Gaba has been located within tomatoes, tea, soybeans, brown rice (germinated) and others. Fermented foods are a particularly good source of this vital amino acid product. Even sourdough bread is a great source of GABA.

In mammals, GABA should be found in high concentrations in the brain.  In fact, somewhere between 60% and 75% of the brain synapses are GABAergic.  

Our bodies naturally produce in our brains to reduce nerve cell activity. So why should you be taking GABA daily?

Improves Sleep

GABA has a calming effect and can naturally help induce sleep by making your nerves less excitable.

One study found that when participants were given GABA, they were able to fall asleep faster. Those with insomnia are likely to produce GABA naturally in lower levels.

https://www.ncbi.nlm.nih.gov/pubmed/26052150

GABA helps to protect the neurons from cell death.  This will assist the brain during sleep’s detoxification and clean-up functions.  

One of the side-effects of drugs such as gabapentin is sleepiness.  Gabapentin acts on one of the GABAergic receptors.  Both baclofen and gabapentin have demonstrated the ability to protect neurons from cell death as well.  

Multiple studies have looked at GABA with regard to sleep improvement and the results are very promising.

Reduce Anxiety

Since GABA mainly works to reduce nerve excitability, it has been linked to reducing the feelings of anxiety and fear. Some anxiety disorders have been associated with low levels of GABA.  GABA is effectively a way to tamp down the excitable effects of a different neurotransmitter, glutamate.  GABA has been used to treat problems such as depression and sleeplessness.  Obviously, lack of sleep would enhance the detrimental symptoms of depression and anxiety. 

A study done in the American Journal of Psychiatry found impaired GABA responses in participants with panic disorder, an anxiety disorder defined by recurring panic attacks.

https://pubmed.ncbi.nlm.nih.gov/15569888/

Benzodiazepines, such as Xanax or Valium, strongly bind a certain GABA receptor actually.  The threshold for seizure, anxiety, panic and stress response are all regulated by certain GABA receptors.  Other GABA receptors manage mood, pain and memory.  Scientists believe that most of the effects of GABA on the brain actually happen in the peripheral nervous system.    

High Blood Pressure

GABA supplements are sometimes used as a natural method to lower blood pressure. Poor sleep and sleeping disorders have been known to contribute to higher blood pressure and hypertension.

In one study, participants with borderline high blood pressure were given a chlorella supplement high in GABA. The results of the study showed a significant reduction in blood pressure.

https://pubmed.ncbi.nlm.nih.gov/19811362/

Animal studies have also shown that ingestion of GAGA-rich foods will decrease blood pressure.  GABA-enriched fermented soybean diets lowered blood pressure.  As well GAGA-rich green tea also reduced blood pressure in hypertensive rats.  Similar findings have been seen in human studies as well.  An intervention with fermented milk, holding between 10 to 12mg of GABA, reduced BP in hypertensive adults.  Another study showed that supplementation of just 80mg of GABA reduced BP in adults with (mild) hypertension.  

Reduce Inflammation

Research has found that GABA has the potential to decrease inflammatory responses. GABA is believed to reduce activity in the nerve pathways that trigger joint inflammation.

One study on mice monitored the supplementation of GABA found that the risk of developing arthritis was reduced and symptoms in those that did develop arthritis were less severe.

https://www.ncbi.nlm.nih.gov/pubmed/21604972

GABAergic circuit alterations are associated with neurodegenerative disorders such as Alzheimer’s and Huntington’s along with Parkinson’s and even simple senile dementia.  

GABA traps reactive intermediates (ROS) created during metabolism.  GABA has been able to capture the ROS created during lipid (cell membrane) peroxidation and to increase the activity of human antioxidant enzymes (superoxide dismutase and glutathione peroxidase). 

Have You Checked Out Our New Sleep Gummy?

Our new Restful Sleep Gummies are formulated with Tart Cherry Extract, Melatonin, and GABA to help your body fall asleep faster, stay asleep longer, and wake up feeling refreshed! This formula does not only help you sleep, it also provides oxidative support that can aid your body in reducing oxidative stress, low-grade inflammation, and more!

ABOUT THE AUTHOR

Dr. Meredith Warner is the creator of Well Theory and The Healing Sole. She is a board-certified Orthopedic Surgeon and Air Force Veteran.

She is on a mission to disrupt traditional medicine practices and promote betterment physically, spiritually and mentally to many more people. She advocates for wellness and functional health over big pharma so more people can age vibrantly with more function and less pain.

At Well Theory, Our surgeon-designed products are FDA Registered and formulated to help people:

  • Manage the symptoms of musculoskeletal pain
  • Recover vibrantly from orthopedic related surgeries
  • Fill the gaps in our daily diets
  • Manage pain associated with inflammation

Reducing Inflammation While You Sleep

Reducing Inflammation While You Sleep

You might not know this but getting a good night’s sleep can greatly help you in reducing your overall inflammation. Many people discount sleep as a passive activity everyone has to do without realizing what great processes occur inside of our bodies while we sleep. It is quite amazing when you look into it. Today let’s take a look at what we can do to reduce inflammation while we sleep.

The Connection Between Sleep And Inflammation

Inflammation is the body’s natural response to outside invaders like bacteria and viruses. Our immune systems (innate and adaptive) are known for protecting our bodies from such infectious agents as well as from toxins and other damaging substances. However, this is the normal and short-lived inflammation that is part of our normal physiology. Most people in the Western world now suffer from a more insidious and damaging inflammation.

Chronic and low-grade inflammation induced by diet, stress, pollutants and high levels of reactive oxygen species is a damaging inflammation that has no place in the proper function of the human body.

When you are trying to sleep, you may find that existing inflammation and pain may feel more noticeable thus making it harder to fall asleep and stay asleep. When we are asleep our immune systems go into overdrive because it is the most ideal time to get to work.

If you have a constant presence of pro-inflammatory proteins and chemical signals in your body, any given source of inflammation to fight off an infection, disease or other cellular damage will be more uncomfortable and cause more havoc on your system.

How To Reduce Inflammation While You Sleep

Better sleep has been associated with lower inflammation levels. So how do we get better sleep? Let’s take a look at what we can do to get better sleep and allow our bodies the time and energy to heal.

Stick To A Schedule

Set a bedtime and an alarm clock. Make sure that you are allowing your body 7-9 hours of sleep each night. Too much and too little sleep can lead to higher levels of inflammation. Try to stick to the recommended hours to keep your body in tip-top shape.

Set The Environment

Make sure that your room is cool and dark. A cool dark room will allow your body a less stressful time to fall asleep and stay asleep. Many believe that the optimal temperature for sleeping is around 65-degrees fahrenheit. This varies of course.

Avoid Blue Light

So many of us spend time on our phones, laptops, or watching TV while lying in bed. Overexposure to blue light can overstimulate the brain thus interrupting your circadian rhythm. Make sure to go into your device settings to turn down the blue light. Blue light is also known to cause oxidative stress in the retina and it should be avoided when possible. Most modern televisions have the ability to reduce the amount of blue light exposure.

Hydrate

Drinking a glass or two before bed can help you sleep better. That is not all that it does! Staying hydrated also reduces inflammation!

Sleep Better With Our New Gummy

Our new Restful Sleep Gummies are formulated with Tart Cherry Extract, Melatonin, and GABA to help your body fall asleep faster, stay asleep longer, and wake up feeling refreshed! This formula does not only help you sleep, but it also provides oxidative support that can aid your body in reducing oxidative stress, low-grade inflammation, and more!

ABOUT THE AUTHOR

Dr. Meredith Warner is the creator of Well Theory and The Healing Sole. She is a board-certified Orthopedic Surgeon and Air Force Veteran.

She is on a mission to disrupt traditional medicine practices and promote betterment physically, spiritually and mentally to many more people. She advocates for wellness and functional health over big pharma so more people can age vibrantly with more function and less pain.

At Well Theory, Our surgeon-designed products are FDA Registered and formulated to help people:

  • Manage the symptoms of musculoskeletal pain
  • Recover vibrantly from orthopedic related surgeries
  • Fill the gaps in our daily diets
  • Manage pain associated with inflammation

[VIDEO] How Our Pain Relief Cream Works

[VIDEO] How Our Pain Relief Cream Works

Dr. Meredith Warner formulated her Pain Relief Cream with PEA, Menthol, Turmeric, and an essential oil blend to topically calm pain naturally. This pain-relieving formulas works on the surface of the skin and penetrates beneath it to relieve pain, inflammation, and irritations.

IT’S EASY TO GET STUCK IN OLD WAYS OF LIVING. IT’S TIME TO MAKE ROOM FOR THE NEW WAYS OF HEALING.

Pain Relief + Recovery Cream

Supportive Topical Therapy To Reduce Pain & Improve Range Of Motion

Dr. Warner’s new pain relief body cream helps relax and recover myofascial tissues, improve the range of motion of ligaments and muscles and cool away the pain with the deep, penetrating power of PEA, anti-inflammatory Essential Oils, and Menthol.

CBD Pain Relief Cream

Dr. Meredith Warner, Orthopedic Surgeon, enhanced this CBD cream with fragrant essential oil blend, Lidocaine, Menthol, and pure Full Spectrum CBD. The holistic blend in our CBD cream is designed to relieve pain on contact, and interact with the endocannabinoid receptors in your body to further regulate inflammation.

3 Easy Ways To Fight Inflammation

3 Easy Ways To Fight Inflammation

Inflammation is a naturally-occurring process in the body. It is typically a sign that the body is fighting off disease or cleaning up tissue damage from use and injury, which is a good thing!

However, infection, disorders, injury, and more can increase these levels of inflammation and lead to long-lasting, serious issues. This happens when the immune system loses its normal balance and starts to create chronic inflammation.

Luckily, there are several ways that you can naturally and easily fight chronic inflammation at home.

HOW CAN INFLAMMATION

strike in the body?

Inflammation can show up in a number of different ways throughout the entire body. Most often, inflammation is felt in the joints. This can be caused by overuse, injury, and disease.

From arthritis to inflammatory conditions like cardiovascular disease, inflammation can attack the body inside and out.

Many people that suffer from skin conditions like eczema or psoriasis also understand the results of chronic inflammation and inflammation that attacks the body itself. Chronic inflammation in the joints generally causes swelling, pain, and damage to cartilage.

In the feet, you may experience inflammatory pain from conditions like rheumatoid arthritis or gout.

  • Gout is a condition caused by an imbalance of uric acid in the body and the formation of uric acid crystals that build up in the joints. As the immune system attempts to rid the body of these crystals, it can cause pain from the inflammation in the affected area.
  • Rheumatoid Arthritis is caused by the breakdown of the lining of the joints, or the synovium. This is when inflammation never stops and is always attacking the body itself.

Both conditions are chronic and cause chronic inflammation.

Other painful conditions can cause pain in the heel and radiate throughout the foot. Such conditions include:

  • Achilles tendonitis, caused by low-levels of chronic inflammation and the degeneration of the tendon connecting your calf muscle and heel together
  • and bursitis, the inflammation of the fluid-filled sacs that cushion the joints, can cause pain in the heel and radiate throughout the foot.

HOW CAN I FIGHT INFLAMATION?

3 ways that you can fight inflammation with ease:

1. PAY ATTENTION TO WHAT YOU’RE EATING.

What you eat plays a huge part in the amount of inflammation your body takes on.

Eating a flavonoid-rich diet full of colorful fruits and vegetables is a sure-fire way to make sure that you are getting necessary natural anti-inflammatories and antioxidants into your daily meals!

Look for recipes that use leafy greens, berries and grapes, fiber-rich nuts, and omega-3 fatty acid-packed fish like salmon and tuna.

2. TAKE ANTI-INFLAMMATORY SUPPLEMENTS.

Daily supplementation is a fantastic practice to fight inflammation and further strengthen your system against future attacks! To protect against inflammation, look for supplements that are packed with anti-inflammatory capabilities, like our Well Theory products.

We try to provide products with both anti-inflammatory and antioxidant capabilities to give you the most optimal health possible.

Our Tart Cherry Extract Supplement is another great option for inflammation relief! Tart Cherry Extract is naturally antioxidant-rich, making it a fantastic weapon against the results of chronic inflammation.

This is one of the best, basic daily supplements for overall wellness you could give to your body and brain.

Dr. Warner is proud to offer these delicious Tart Cherry Extract Gummies designed to help you improve sleep patterns, joint mobility, muscle recovery, and getting your inflammation under control. 

This Restful Sleep Gummy not only may help you fall asleep, but may provide oxidative support to aid your body’s natural recovery from oxidative stress, low-grade inflammation, and more.

3. EXERCISE!

This should go without saying, but exercise is a great way to keep excess weight and pressure off of your muscle and joints! A minimum of thirty minutes of exercise each day, or at least four times a week, can do wonders for your full-body health and for fighting inflammation.

The real benefit of exercise is that it induces changes at the cellular level that promote free-radical scavenging and reduced levels of chronic inflammatory proteins.

Look for workout routines that are easy on your joints, like yoga and tai chi.

Don’t underestimate the power of simple choices like taking the stairs, parking further out at the grocery store, or even doing yard work!

These are three simple ways to control inflammation levels that you can build into your daily lifestyle. Pair this with getting lots of water throughout your day and plenty of restful sleep to keep your system free of stress and inflammation. Make these common practices for active, everyday relief!

ABOUT THE AUTHOR

Dr. Meredith Warner is the creator of Well Theory and The Healing Sole. She is a board-certified Orthopedic Surgeon and Air Force Veteran.

She is on a mission to disrupt traditional medicine practices and promote betterment physically, spiritually and mentally to many more people. She advocates for wellness and functional health over big pharma so more people can age vibrantly with more function and less pain.

At Well Theory, Our surgeon-designed products are FDA Registered and formulated to help people:

  • Manage the symptoms of musculoskeletal pain
  • Recover vibrantly from orthopedic related surgeries
  • Fill the gaps in our daily diets
  • Manage pain associated with inflammation

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How Tart Cherry May Help With Fibromyalgia

How Tart Cherry May Help With Fibromyalgia

Fibromyalgia is a painful condition that is accompanied by widespread pain, fatigue, and sometimes there are mental health consequences or cognitive impairments. This is considered a problem on a spectrum of central sensitization syndromes. Some also consider this to be an endocannabinoid deficiency syndrome. Others simply refer to fibromyalgia as ‘’myositis’ or inflamed muscle.

There is no known cure for fibromyalgia; however, there are many medicines available that can help control symptoms. There are also remedies that can halt the root causes of these symptoms.

What Does Fibromyalgia Do To The Body?

Fibromyalgia symptoms have been observed to flare-up after an event of physical trauma, infection, surgery, or psychological stress. Symptoms can build slowly or appear suddenly.

Pain associated with fibromyalgia is generally described as a dull ache and can manifest almost anywhere on the body. However, sometimes, there are sharp and distinct areas of pain.

Most of the time, the pain is in muscle or fascial tissues. The severity of pain often interrupts sleep and can cause brain fog. There are mood disorders associated with this condition.

What Is The Cause Of Fibromyalgia?

Researchers have found that the condition can develop due to genetics, certain types of infections, or certain types of physical or emotional trauma. As with many such chronic and painful conditions, there is generally a basic problem with inflammation and also oxidative stress damaging cells and causing pain.

Pain associated with fibromyalgia is thought to be caused by an abnormal increase of chemicals (neurotransmitters) that stimulates and triggers pain receptors. Researchers believe that these pain receptors become sensitive and overreact to stimuli. In other words, such receptors trigger what the brain considers pain even with simple and normal movements or touches.

Tart Cherry As A Form Of Fibromyalgia Pain Management

Many people with fibromyalgia utilize prescription and over-the-counter pain relievers to manage their pain. Over-the-counter NSAIDs are by far the most common types of pain relievers. NSAIDs have some side effects associated with long-term use such as stomach ulcers and an increased risk of strokes and heart attacks. Narcotics are often prescribed for this condition as well. However, the risks of narcotics are so many and so horrible, that these are not really a good choice for most people.

Tart Cherries are a natural anti-inflammatory that targets some of the same enzymes as NSAIDs, but in a much more gentle manner with none of the same types of side-effects. Tart Cherry is a Cox-2 inhibitor that is not known to have the same side effects as NSAIDs. Cherries also are packed with antioxidants, which help keep your free radical levels low. Increasing your antioxidant intake can help reduce low-grade inflammation, reduce brain fog, increase energy levels, and more. Indeed, the fundamental source of what we call pain is generally damage to cells and stimulation of nerve fibers from the mechanisms of inflammation and oxidative stress.

This study found that participants with fibromyalgia experienced less pain when they drank 2 bottles 10.5 oz a day for 10 days.

Give Our Tart Cherry Extract A Try

Our Tart Cherry Extract contains 1500 mg of tart cherry. This extract gives you all the benefits of tart cherry juice, without the added sugars and bitter taste!

ABOUT THE AUTHOR

Dr. Meredith Warner is the creator of Well Theory and The Healing Sole. She is a board-certified Orthopedic Surgeon and Air Force Veteran.

She is on a mission to disrupt traditional medicine practices and promote betterment physically, spiritually and mentally to many more people. She advocates for wellness and functional health over big pharma so more people can age vibrantly with more function and less pain.

At Well Theory, Our surgeon-designed products are FDA Registered and formulated to help people:

  • Manage the symptoms of musculoskeletal pain
  • Recover vibrantly from orthopedic related surgeries
  • Fill the gaps in our daily diets
  • Manage pain associated with inflammation