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PEA And Brain Health

At Well Theory, we offer PEA in a few of our formulations because of its amazing anti-inflammatory benefits. However, PEA (Palmitoylethanolamide) is so much more than an anti-inflammatory. Many consider PEA to be a natural and safe painkiller.

This naturally occurring substance is a fatty acid amide. It is derived from essential fatty acids in our diets. PEA is made from palmitic acid which is a product of normal fatty acid synthesis in our bodies. PEA creation is dependent upon source materials from our diets. As most Americans have terrible diets, most also lack this natural painkiller and anti-inflammatory substance.

PEA is a necessary aspect of a healthy nervous and immune system. PEA has the potential to bring about the following benefits:

  • Boost brain performance
  • Create a sense of well-being
  • Improve clarity and reduce brain fog

But how can this one supplement accomplish so much? When you look at how it is naturally produced within the body and its function within our cells, you have your answer. Most of us do not make enough PEA to combat the massive amounts of chronic inflammation from our environment, stressful lives, and diets.

The Role PEA Plays In Brain Health

PEA works in the brain to amplify the activity of your neurotransmitters. This means that it can increase the activity and release of hormones such as dopamine (which creates an overall sense of well-being and lessens anxiety,) serotonin (a natural mood stabilizer that also sends signals to the body to aid sleeping, digestion, sleep,) acetylcholine (memory and brain clarity) norepinephrine (concentration, attention, and wakefulness,) and so much more.

In other words, PEA works to enhance your body’s natural beneficial functions. It stimulates your neurotransmitters to increase the volume of activity, promoting the production of hormones that relieve pain while calming neurotransmitters that promote inflammation.

It also works to enhance brain performance by stimulating the production of hormones associated with concentration, wakefulness, and memory support.

In addition to these benefits, PEA has also been found to be neuroprotective. This means that it has a balancing effect on your neurotransmitters – preventing over-production of certain hormones while stimulating otherwise under-productive neural transmissions. Emerging studies indicate that it essentially keeps your neurotransmitters in check and in balance.

This results in noticeably improved mood, energy, and enhanced brain function.

PEA is also extremely active on the support cells of the nervous system and brain. It enhances the normal and good functionality of cells such as microglia or astrocytes. These support cells are mandatory for good nervous system outcomes.

How To Take PEA

Your body naturally produces PEA – so supporting a healthy body is the best way to boost PEA production. You can get PEA from your diet and supplements as well. Most of us do not consume enough of the base source of the fatty acids for the formation of PEA; therefore, we believe that supplementation is beneficial.

Read More: Natural Sources Of PEA

Our Essential Multivitamin is formulated with PEA to deliver a boost of PEA while also delivering clinical-strength dosings of essential vitamins and minerals. This multi is therefore designed to help boost natural PEA production through improved nutrition, while the added PEA in the formulation actively works to reduce inflammation, clear brain fog, and deliver all the benefits described above.


Dr. Meredith Warner is the creator of Well Theory and The Healing Sole. She is a board-certified Orthopedic Surgeon and Air Force Veteran.

She is on a mission to disrupt traditional medicine practices and promote betterment physically, spiritually and mentally to many more people. She advocates for wellness and functional health over big pharma so more people can age vibrantly with more function and less pain.

At Well Theory, Our surgeon-designed products are FDA Registered and formulated to help people:

  • Manage the symptoms of musculoskeletal pain
  • Recover vibrantly from orthopedic related surgeries
  • Fill the gaps in our daily diets
  • Manage pain associated with inflammation

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