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The Complete Beginner's Guide To PEA

The Complete Beginner's Guide To PEA

Hi, Dr. Meredith Warner here -

I discovered palmitoylethanolamide (PEA) during my quest to improve my knowledge and applications of natural remedies for my patients, my family, and myself. 

PEA is one molecule in a family of natural and endogenous fatty acids (meaning that they exist within the human body) that act on a variety of receptors. PEA is of the same family that anandamides are, or the neurotransmitters that are affected by CBD.

PEA, along with oleoylethanolamide (OEA) and other N-acylethanolamines (NAEs), are biologically active lipids. PEA is a strong and natural anti-inflammatory and is essentially devoid of unwanted effects in humans. It is also useful for treating eczema, controlling pain, and preventing neurodegeneration among other benefits.

PEA is naturally present within human beings and is produced on demand in the lipid bilayer of cells. It has a short half-life and is metabolized when not needed. When taken orally, it has a high volume of distribution throughout the body and is especially effective in the brain and for nervous tissues.

PEA is found in high levels during several inflammatory and painful disorders due to its innate anti-inflammatory activities. It basically functions as an internal regulator of pain.

How PEA Works

a natural option for pain + inflammation relief

PEA in all available clinical trials produces significant pain relief without any side effects. This is true for pain intensity in patients with chronic pain and/or neuropathic pain, too.

PEA acts mostly on non-neuronal cells of the nervous system. Current thinking in chronic and neuropathic pain targets these cells as they are most responsible for the actual sensation of pain. This is sometimes called gliopathic pain or asteropathic pain.

It has been discovered that mast cells are particularly active around peripheral nerve endings in the pain situations. PEA downregulates the inflammatory and stimulatory activities of the mast cells. Peripheral mast cells are pro-nociceptive (pain-perceiving). PEA is anti-nociceptive (blocks pain perception). PEA targets receptors and cellular activities that are not traditional to common pain medications.

PEA is a cannabimimetic compound, meaning PEA works with cannabinoid receptors within the body. It is also known as an indirect endocannabinoid.

PEA should be a daily supplement to enhance the activities of the family of lipids to which it belongs. PEA is natural and is normally produced by the human body. Most of us are likely deficient. PEA is an indirect endocannabinoid and as such plays an important role in the endogenous regulatory system of the endocannabinoids.


PEA is naturally analgesic (anti-pain), anti-inflammatory, and will downregulate mast cells’ activities and thus protect peripheral nerve endings. PEA is great for the brain and acts on the support cells such as the glial cells and astrocytes.

If you do not have enough PEA, you will lack the full regulatory ability of the endocannabinoid system. This means that all other systems in your body will lack balance.

PEA is a natural way to produce many of the same effects as CBD.

PEA may help control pain in these conditions:

  • Injury
  • Intestinal inflammation
  • Chronic migraine
  • Neuropathic pain
  • Cerebral ischemia
  • Multiple Sclerosis (MS)
  • Sciatica
  • Post-laminectomy syndrome
  • Fibromyalgia
  • Rheumatoid arthritis
  • Diabetic neuropathy
  • Post-operative pain
  • TMJ pain from arthritis
  • Arthritis pain
  • Lower Back Pain (LBP)
  • Nerve-mediated pain like carpal tunnel and tarsal tunnel
  • Primary dysmenorrhea

Purposefully-Paired All-Natural Ingredients

Realizing the potential of PEA in natural anti-inflammatory recovery, Dr. Warner has developed Well Theory products exclusively for our sister company, The Healing Sole. 

The essential PEA multivitamin, stand-alone PEA supplement, Joint Health Multi with PEA, Pain Relief + Recovery Cream, and pain-relieving foot cream from Well Theory has been purposefully-crafted by Dr. Meredith Warner to relieve pain naturally, effectively, and quickly. 

The ingredients combined within these products work together to regulate homeostasis, reduce inflammation, and support stronger, healthier muscles.

Find Natural Relief

with the full line of Dr. Warner's Well Theory products

For these reasons, PEA is the essential ingredient in many of our products. Our Well Theory product line as a whole is designed to help you live life better – with less pain, better health, and a vibrancy that radiates from within.

Dr. Meredith Warner Baton Rouge Orthopedic Surgeon

Dr. Meredith Warner is the creator of Well Theory and The Healing Sole. She is a board-certified Orthopedic Surgeon and Air Force Veteran.

She is on a mission to disrupt traditional medicine practices and promote betterment physically, spiritually and mentally to many more people. She advocates for wellness and functional health over big pharma so more people can age vibrantly with more function and less pain.

At Well Theory, Our surgeon-designed products are FDA Registered and formulated to help people:

  • Manage the symptoms of musculoskeletal pain
  • Recover vibrantly from orthopedic related surgeries
  • Fill the gaps in our daily diets
  • Manage pain associated with inflammation

Surgeon Formulated
For Your Peace of Mind

Natural Ingredients + Cutting-Edge Medical Breakthroughs.